- 英文名称
- GO-203 TFA salt
- 分子式
- C89H171F3N52O21S2
- 分子量
- 2426.77
- 中文别名
- 穿膜抑制肽; D型穿膜肽GO-203; 化合物GO-203; D-{ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-CYS-GLN-CYS-ARG-ARG-LYS-ASN} 全D型三氟乙酸盐; (6R,9R,12R,15R,18R,21R,24R,27R,30R,33S,36R,39S,42R,45R,48R,51R)-1,6-二氨基-51-(2-氨基-2-氧代乙基)-36-(3-氨基-3-氧代丙基)-48-(4-氨基丁基)-9,12,15,18,21,24,27,30,42,45-十(3-胍基丙基)-1-亚氨基-33,39-双(巯基甲基)-7,10,13,16,19,22,25,28,31,34,37,40,43,46,49-十五氧代-2,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-十六氮杂五十二烷-52-酸三氟乙酸盐; GO-203; GO-203 Tfa; H-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Cys-D-Gln-D-Cys-D-Arg-D-Arg-D-Lys-D-Asn-OH trifluoroacetic acid (1:1); D-Arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-cysteinyl-D-glutaminyl-D-cysteinyl-D-arginyl-D-arginyl-D-lysyl-D-asparagine trifluoroacetic acid (1:1); (6R,9R,12R,15R,18R,21R,24R,27R,30R,33S,36R,39S,42R,45R,48R,51R)-1,6-Diamino-51-(2-amino-2-oxoethyl)-36-(3-amino-3-oxopropyl)-48-(4-aminobutyl)-9,12,15,18,21,24,27,30,42,45-decakis(3-guanidinopropyl)-1-imino-33,39-bis(mercaptomethyl)-7,10,13,16,19,22,25,28,31,34,37,40,43,46,49-pentadecaoxo-2,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-hexadecaazadopentacontan-52-oic acid 2,2,2-trifluoroacetic acid salt
- 用途
- 化学合成；作为D型氨基酸肽段，具有细胞通透性，抑制MUC1-C二聚化从而抑制致瘤作用；在体外研究中，可下调TIGAR蛋白，调节AKT-S6K1-elF4A信号并抑制p-AKT，增加ROS和线粒体跨膜电位损失；在体内小鼠移植瘤模型中，能抑制MUC1阳性大肠癌细胞生长和生存，在乳腺、前列腺移植瘤及肺癌和某些恶性血液病中具有抗瘤活性。
