- 英文名称
- Amitriptyline-d6 Hydrochloride
- 分子式
- C20H18D6ClN
- 分子量
- 319.9
- 中文别名
- 盐酸阿米替林-D6; 氘代阿米替林盐酸盐-d6; 阿米替林-D6 HCL; 六氘代阿米替林盐酸盐; 盐酸阿米替林-D6氘代; [2H6]-盐酸阿米替林; [2H6]-阿米替林盐酸盐; 阿米替林-D6 HCL(N,N-二甲基-D6); Amitriptyline-d6 HCl; Amitriptyline hcl (d6); 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-di(methyl-d)-, hydrochloride; 3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-bis[(H)methyl]propan-1-amine hydrochloride; 3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-bis[(H)methyl]-1-propanamine hydrochloride; 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine-d6 Hydrochloride; 3-(10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine-d6 Hydrochloride; Amitriptyline-d6 (hydrochloride); Amitriptyline-d6 hydrochloride (N,N-dimethyl D6); 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-di(methyl-d3)-, hydrochloride; AMITRIPTYLINE HCL (N,N-DIMETHYL-D6); 3-(5,6-dihydrodibenzo[2,1-b:2',1'-f][7]annulen-11-ylidene)-N,N-bis(trideuteriomethyl)propan-1-amine
- 用途
- Amitriptyline-d6 (hydrochloride) 是 Amitriptyline hydrochloride 的氘代物。Amitriptyline hydrochloride 是一种血清素再摄取转运体 (SERT) 和去甲肾上腺素再摄取转运体 (NET) 抑制剂，对人的 SERT 和 NET 作用的 Ki 值分别为 3.45 nM 和 13.3 nM。Amitriptyline hydrochloride 还与多巴胺再摄取转运体 (DAT) 结合，其 Ki 为 2.58 μM。Amitriptyline hydrochloride 也抑制肾上腺素能受体、毒蕈碱受体、组胺受体、5-羟色胺受体。Amitriptyline hydrochloride 是一种具有强神经营养活性的 TrkA 和 TrkA 受体激动剂。Amitriptyline hydrochloride 具有抗抑郁作用。
