- 英文名称
- Vancomycin
- 分子式
- C66H75Cl2N9O24
- 分子量
- 1449.25
- 中文别名
- 万古霉素碱; (3S,6R,7R,22R,23S,26S,36R,38AR)-3-(2-氨基-2-氧代乙基)-44-[[2-O-(3-氨基-2,3,6-三脱氧-3-C-甲基-α-L-lyxo-己吡喃糖基)-β-D-吡喃葡萄糖基]氧基]-10,19-二氯-2,3,4,5,6,7,23,24,25,26,36,37,38,38A-十四氢-7,22,28,30,32-五羟基-6-[[[(2R)-4-甲基-2-(甲基氨基)-1-氧戊基]氨基]-2,5,24,38,39-五氧基-22H-8,11:18,21-二苯酚-23,36-(亚氨基甲基)-13,16:31,35-二甲-1H,16H-[1,6,9]恶二氮杂环十六烷[4,5-M][10,2,16]苯并恶二氮杂环四辛因-26-羧酸; Vancomycin Base; Vancomycin (base and/or unspecified salts); (3S,6R,7R,22R,23S,26S,36R,38aR)-3-(2-Amino-2-oxoethyl)-44-[[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranosyl]oxy]-10,19-dichloro-2,3,4,5,6,7,23,24,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-[[(2R)-4-methyl-2-(methylamino)-1-oxopentyl]amino]-2,5,24,38,39-pentaoxo-22H-8,11:18,21-Dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-1H,16H-[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid; (1S,2R,18R,19R,22S,25R,28R,40S)-22-(2-Amino-2-oxoethyl)-48-{[(5ξ)-2-O-(3-amino-2,3,6-trideoxy-3-methyl-α-L-lyxo-hexopyranosyl)-β-D-xylo-hexopyranosyl]oxy}-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2.2.1.1.0.0]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid
- 用途
- 万古霉素用于革兰阳性菌严重感染，尤其是对其他抗菌药耐药或疗效差的耐甲氧西林金黄色葡萄球菌、表皮葡萄球菌、肠球菌所致的严重感染；限用于耐甲氧苯青霉素的金黄色葡萄球菌（MRSA）所致的系统感染和难辨梭状芽胞杆菌所致的肠道感染和系统感染；青霉素过敏者不能采用青霉素类或头孢菌素类，或经上述抗生素治疗无效的严重葡萄球菌感染患者，可选用万古霉素。本品也用于对青霉素过敏者的肠球菌心内膜炎、棒状杆菌属（类白喉杆菌属）心内膜炎的治疗。对青霉素过敏与青霉素不过敏的血液透析患者发生葡萄球菌属所致动、静脉分流感染的治疗。
