- 英文名称
- Quinaldopeptin
- 分子式
- C62H78N14O14
- 分子量
- 1243.37
- 中文别名
- Quinaldopeptin; Quinaldopeptin; RefChem:930467; CHEMBL5425415; CHEBI:219776; GLXC-27468; 3-hydroxy-N-[(3R,4R,7S,20S,27R,28R,31S,44S)-27-[(3-hydroxyquinoline-2-carbonyl)amino]-4,15,28,39-tetramethyl-2,6,13,16,19,26,30,37,40,43-decaoxo-1,5,12,15,18,25,29,36,39,42-decazapentacyclo[42.4.0.07,12.020,25.031,36]octatetracontan-3-yl]quinoline-2-carboxamide; N,N'-((7R,8R,10aS,22aS,29R,30R,32aS,44aS)-8,18,30,40-Tetramethyl-6,10,16,19,22,28,32,38,41,44-decaoxotetratetracontahydrotetrapyrido[1,2-a:1',2'-j:1'',2''-q:1''',2'''-z][1,4,7,10,13,17,20,23,26,29]decaazacyclodotriacontine-7,29-diyl)bis(3-hydroxyquinoline-2-carboxamide)
- 用途
- 化学合成；作为抗生素，对革兰氏阳性菌和厌氧菌具有高活性，对B16黑色素瘤细胞具有明显毒性；体外研究显示对B16-F10细胞活性较高，IC50值约为chromomycin A3的3倍；体内研究显示在0.03~0.01 mg/kg剂量下对P388荷瘤小鼠有轻微延长生存期作用，但抗肿瘤活性有限。
