- 英文名称
- 4-O-Methylhonokiol
- 分子式
- C19H20O2
- 分子量
- 280.36
- 中文别名
- 4'-甲氧基-3',5-二-2-丙烯基-(1,1'-联苯)-2-醇; 4-甲氧基-3,5-二丙烯基-(1,1'-联苯)-2-醇; 4-O-和厚朴酚; 4-O-甲基和厚朴酚; 4-甲基和厚朴酚; 4'-O-甲基和厚朴酚; 2-(4-methoxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol; 4-O-Methyl honokiol; [1,1'-Biphenyl]-2-ol, 4'-methoxy-3',5-di-2-propen-1-yl-; 4'-Methoxy-3',5-di-2-propen-1-yl[1,1'-biphenyl]-2-ol; 4'-methoxy-3',5-di-2-propyleneyl-(1,1'-biphenyl)-2-ol; 3,5'-diallyl-2'-hydroxy-4-methoxy-1,1'-biphenyl; 3,5'-diallyl-2'-hydroxy-4-methoxybiphenyl; METHYLHONOKIOL; methoxyhonokiol; 4-methoxyhonokiol; 4'-O-Methylhonokiol
- 用途
- - 生物活性
4-O-Methyl honokiol 是从厚朴中分离到的木脂素类化合物，为 PPARγ 的激动剂，可抑制 NF-κB 的活性，用于癌症，炎症等研究。
- 靶点
PPARγ
NF-κB
- 体外研究
4-O-Methyl honokiol is a natural neolignan isolated from
Magnolia officinalis
, acts as a PPARγ agonist, and inhibtis NF-κB activity. 4-O-Methyl honokiol (20 μM) increases the expression, transcription and DNA binding activities, and nuclear translocation of PPARγ in both in prostate PC-3 and LNCap cells. 4-O-Methyl honokiol (0-30 μM) inhibits LNCaP and PC-3 cancer cells growth, causes G0/G1 phase arrest and induces apoptotic cell death, and such effects can be reversed by PPARγ antagonist. 4-O-Methyl honokiol inhibits NF-κB activity and cancer cell growth, but such effects as well as its activation of PPARγ can be abolished by knock-down of p21. 4-O-methylhonokiol (0.5, 1 and 2 μM) reduces LPS-induced release of NO, PGE2, ROS, TNF-α and IL-1β in cultured astrocytes, and amyloidogenesis in cultured astrocytes and microglial BV-2 cells.
- 体内研究
4-O-Methyl honokiol (40 or 80 mg/kg, i.p. everyday for 4 weeks) inhibits the growth of SW620 and PC3 tumours in SW620 and PC3 xenograft model. 4-O-Methyl honokiol significantly increases the expression of p21 and PPARγ in the tumour tissues. 4-O-Methyl honokiol (0.5 or 1 mg/kg/day daily for 3 weeks) significantly ameliorates LPS-induced memory impairment, and inhibits LPS-induced iNOS and COX-2 expression in mice. 4-O-Methyl honokiol also shows inhibitory activities against the Aβ
1-42
accumulation, and activates astrocytes and microglia in LPS-injected mice brain.
- 用于含量测定/鉴定/药理实验等。
