- 英文名称
- Gimatecan
- 分子式
- C25H25N3O5
- 分子量
- 447.48
- 中文别名
- (S,E)-4-乙基-4-羟基-3,14-二氧代-3,4,12,14-四氢-1H-吡喃并[3',4':6,7]吲哚嗪并[1,2-b]喹啉-11-甲醛 O-(叔丁基)肟; 化合物Gimatecan; 化合物 T21319; (S,E)-4-Ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-11-carbaldehyde O-(tert-butyl) oxime; 7-[(E)-tert-butyloxyiminomethyl]-camptothecin; trans-1-Hydroxy-7-phenyl-hepten-(2)-diin-(4,6); 7-Phenyl-hept-2t-en-4,6-diin-1-ol; 7-tert-butoxyiminomethylcamptothecin; (E)-7-phenyl-2-hepten-4,6-diyn-1-ol; 7-phenyl-hept-2t-ene-4,6-diyn-1-ol; ST-1481; 1-Phenyl-hepten-(5)-trans-diin-(1.3)-ol-(7); trans-7-Phenyl-hepten-(2)-diin-(4.6)-ol-(1); 2-Heptene-4,6-diyn-1-ol,7-phenyl-,(E); (4S)-11-[(E)-(tert-butoxyimino)methyl]-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 7-(t-butoxy)iminomethylcamptothecin; (E)-7-tert-butoxyiminomethyl-camptothecin; 7-hydroxy-1-phenyl-hept-5E-ene-1,3-diyne; (4S)-4-Ethyl-4-hydroxy-11-[(E)-{[(2-methyl-2-propanyl)oxy]imino}methyl]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; ST1481; CPT 184; LBQ707; 7-T-Butoxyiminomethylcamptothecin
- 用途
- 作为有效的拓扑异构酶I抑制剂;具有口服活性的喜树碱类似物;具有抗肿瘤活性;用于抑制人膀胱癌模型(HT1376和MCR)的生长;用于抑制裸鼠体内HT1376肿瘤的生长
