- 英文名称
- (3E,5S)-5-(Hydroxymethyl)-3-(hydroxy{(1S,2R,4aS,6R,8aR)-1,3,6-trimethyl-2-[(1E)-1-propen-1-yl]-1,2,4a,5,6,7,8,8a-octahydro-1-naphthalenyl}methylene)-1-methyl-2,4-pyrrolidinedione
- 分子式
- C23H33NO4
- 分子量
- 387.51
- 中文别名
- 抗生素CJ-21058; CEC-21058,SECA抑制剂; CJ-21058,SECA抑制剂; 化合物CJ-21058; (S,E)-3-(Hydroxy((1S,2R,4aS,6R,8aR)-1,3,6-trimethyl-2-((E)-prop-1-en-1-yl)-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)methylene)-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione; CJ-21058; 2,4-Pyrrolidinedione, 5-(hydroxymethyl)-3-[(1S,2R,4aS,6R,8aR)-hydroxy[1,2,4a,5,6,7,8,8a-octahydro-1,3,6-trimethyl-2-(1E)-1-propen-1-yl-1-naphthalenyl]methylene]-1-methyl-, (3E,5S)-
- 用途
- (3E,5S)-5-(羟基甲基)-3-[(1S,2R,4AS,6R,8AR)-羟基[1,2,4A,5,6,7,8,8A-八氢-1,3,6-三甲基-2-(1E)-1-丙烯-1-基-1-萘基]亚甲基]-1-甲基-2,4-吡咯烷二酮是一种有效的SecA抑制剂，其IC50值为15 µg/mL；可抑制ATP依赖性前体蛋白跨细菌细胞膜的易位；对革兰氏阳性菌具有抗菌活性。
