- 英文名称
- (3E,5E)-1-[(2,5-Dihydro-1-hydroxy-2,2,5,5-tetramethyl-1H-pyrrol-3-yl)methyl]-3,5-bis[(4-fluorophenyl)methylene]-4-piperidinone
- 分子式
- C28H30F2N2O2
- 分子量
- 464.55
- 中文别名
- HO-3867; 化合物HO-3867; (3E,5E)-1-[(2,5-二氢-1-羟基-2,2,5,5-四甲基-1H-吡咯-3-基)甲基]-3,5-二[(4-氟苯基)亚甲基]-4-哌啶酮; STAT3抑制剂HO-3867; 化合物HO3867; 抑制剂HO-3867; HO-3867; 4-Piperidinone, 1-[(2,5-dihydro-1-hydroxy-2,2,5,5-tetramethyl-1H-pyrrol-3-yl)methyl]-3,5-bis[(4-fluorophenyl)methylene]-, (3E,5E); (3E,5E)-3,5-bis[(4-fluorophenyl)methylidene]-1-[(1-hydroxy-2,2,5,5-tetramethylpyrrol-3-yl)methyl]piperidin-4-one; DAP-F(p)-NOH; (3E,5E)-3,5-bis[(4-fluorophenyl)methylene]-1-[(1-hydroxy-2,2,5,5-tetramethyl-pyrrol-3-yl)methyl]piperidin-4-one; (3E,5E)-3,5-bis[(4-fluorophenyl)methylidene]-1-[(1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl]piperidin-4-one; (3E,5E)-3,5-Bis(4-fluorobenzylidene)-1-[(1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl]-4-piperidinone; 1-[(2,5-dihydro-1-hydroxy-2,2,5,5-tetramethyl-1H-pyrrol-3-yl)methyl]-3,5-bis[(4-fluorophenyl)methylene]-(3E,5E)-4-piperidinone
- 用途
- 作为姜黄素类似物，是选择性STAT3抑制剂，用于化学合成；体外研究显示其对卵巢癌细胞系有显著细胞毒性，诱导细胞周期阻滞和凋亡，阻断JAK/STAT3通路；体内研究表明口服可抑制卵巢癌异种移植瘤生长，增敏顺铂耐药性卵巢癌，减弱左心室衰竭诱发的肺动脉高血压。
