3-(6-甲基-2-吡啶基)-N-苯基-4-(4-喹啉基)-1H-吡唑-1-硫代甲酰胺; 3-(6-甲基-2-吡啶基)-N-苯基-4-(4-喹啉基)吡唑-1-硫代甲酰胺; A 83-01; A83-01; ALK5抑制剂IV; ALK4、5和7激酶抑制剂; 3-(6-methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide; A-83-01; ALK5 Inhibitor IV; cc-656; TGF inhibitor A-83-01; 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide; TGF-β RI Kinase Inhibitor IV
用途
化学合成；生命科学，细胞培养用；作为TGF-β type I receptor (ALK5-TD)抑制剂，IC50值为12 nM；抑制activin/nodal type I receptor (ALK4-TD)和nodal type I receptor (ALK7-TD)诱导的转录，IC50值分别为45 nM和7.5 nM；现配现用。
