- 英文名称
- Meleagrin
- 分子式
- C23H23N5O4
- 分子量
- 433.46
- 中文别名
- 化合物MELEAGRIN; 化合物 T16035; meleagrine; [3E,7aR,12aS,(-)]-7a-(1,1-Dimethyl-2-propenyl)-7a,12-dihydro-6-hydroxy-3-(1H-imidazole-4-ylmethylene)-12-methoxy-1H,5H-imidazo[1',2':1,2]pyrido[2,3-b]indole-2(3H),5-dione; 8,9-dehydroneoxaline; 6-O-Methyloxaline, Meleagrine; 1H,5H-Imidazo[1',2':1,2]pyrido[2,3-b]indole-2,5(3H)-dione, 7a-(1,1-dimethyl-2-propen-1-yl)-7a,12-dihydro-6-hydroxy-3-(1H-imidazol-5-ylmethylene)-12-methoxy-, (3E,7aR,12aS)-; (7AR,12aS,E)-3-((1H-imidazol-5-yl)methylene)-6-hydroxy-12-methoxy-7a-(2-methylbut-3-en-2-yl)-7a,12-dihydroimidazo[1',2':1,2]pyrido[2,3-b]indole-2,5(1H,3H)-dione; (1S,9R,14E)-11-hydroxy-14-[(1H-imidazol-5-yl)methylidene]-2-methoxy-9-(2-methylbut-3-en-2-yl)-2,13,16-triazatetracyclo[7.7.0.01,13.03,?]hexadeca-3(8),4,6,10-tetraene-12,15-dione
- 用途
- 化学合成；作为FabI抑制剂；作为主要的c-Met抑制实体，有助于控制c-Met依赖性转移和侵袭性乳腺癌；抑制人乳腺癌细胞系MDA-MB-231、MDA-468、BT-474、SK BR-3、MCF7和MCF7-dox的生长；对HGF诱导的乳腺癌细胞系迁移和侵袭产生剂量依赖性抑制；在原位无胸腺裸鼠模型中有效抑制侵袭性三阴性乳腺肿瘤细胞生长
