- 英文名称
- 20alpha-Hydroxycholesterol
- 分子式
- C27H46O2
- 分子量
- 402.65
- 中文别名
- 5-胆甾烯-3β,20α-二醇; (8S,9S,10R,13S,14S,17S)-17-((R)-2-羟基-6-甲基庚烷-2-基)-10,13-二甲基-2,3,4,7,8,9,10,11,12,13,14,15,16,17-十四氢-1H-环戊二烯并[A]菲-3-醇; 胆固醇杂质32; 20(S)羟基胆固醇; 5-Cholestene-3B,20a-diol; Cholest-5-ene-3,20-diol, (3.beta.)-; 5-cholestene-3β,20α-diol; (3S,8S,9S,10R,13S,14S,17S)-17-[(2R)-2-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol; (20S)-Cholest-5-ene-3,20-diol; (3S,8S,9S,10R,13S,14S,17S)-17-((S)-2-hydroxy-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol; 20-hydroxycholesterol; 20α-Hydroxy Cholesterol
- 用途
- 20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) 是平滑 (smo) 癌蛋白的变构激活剂，在以 NIH3T3 细胞的基因转录报告实验中，激活 hedgehog (Hh) 信号通路的 EC50 值为 3 μM；靶点为 Human Endogenous Metabolite。
