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抗菌素

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(Z)-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-乙酰氧基-3,11-二羟基-4,8,10,14-四甲基十二氢-1H-环戊二烯并[a]菲-17(2H,10H,14H)-亚基)-6-甲基庚-5-烯酸钠盐
英文名称
Sodium (Z)-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetoxy-3,11-dihydroxy-4,8,10,14-tetramethyldodecahydro-1H-cyclopenta[a]phenanthren-17(2H,10H,14H)-ylidene)-6-methylhept-5-enoate
CAS号
751-94-0
分子式
C₃₁H₄₇NaO₆
分子量
538.69
中文别名
夫西地酸钠; Sodium (3α,4α,5α,8α,9β,11α,13α,14β,16β,17Z)-16-acetoxy-3,11-dihydroxy-4,8,14-trimethyl-18-norcholesta-17,24-dien-21-oate; MFCD00865135; 5-Heptenoic acid, 2-[(3α,4α,5α,8α,9β,11α,13α,14β,16β,17Z)-16-(acetyloxy)-3,11-dihydroxy-4,8,10,14-tetramethylgonan-17-ylidene]-6-methyl-, sodium salt, (2Z)- (1:1); Sodium (2Z)-2-[(3α,4α,5α,8α,9β,11α,13α,14β,16β,17Z)-16-acetoxy-3,11-dihydroxy-4,8,10,14-tetramethylgonan-17-ylidene]-6-methylhept-5-enoate; (3a,4a,8a,9b,11a,13a,14b,16b,17Z)-16-(Acetyloxy)-3,11-dihydroxy-29-nordammara-17(20),24-dien-21-oic Acid Monosodium Salt; sodium (2Z)-2-[(3α,4α,5α,8α,9β,11α,13α,14β,16β,17Z)-16-(acetyloxy)-3,11-dihydroxy-4,8,10,14-tetramethylgonan-17-ylidene]-6-methylhept-5-enoate; EINECS 212-030-3; Fusidate Sodium; Sodium fusidate; Fusidic acid sodium; Sodium 3a,11a,16b-Trihydroxy-29-nor-8a,9b,13a,14b-dammara-17(20),24-dien-21-oate 16-Acetate; Fusidic acid sodium salt; Fusidic acid (sodium salt)
用途
生化研究；制药，抗革兰氏阴性菌；在细菌、细菌溶胞产物中抑制蛋白质合成；作为窄谱抗生素，用于敏感菌所致的周围感染，对耐其他抗生素的菌株尤为适宜，常用于皮肤、骨组织及关节等部位感染以及心内膜炎等；治疗由各种敏感细菌尤其是葡萄球菌引起的感染，如骨髓炎、败血症、心内膜炎、反复感染的囊性纤维化、细菌性心肌内膜炎、肺炎、脑膜炎、白喉、结核、皮肤及软组织感染、外科及创伤性感染等；静脉给药用于严重感染或耐药菌株感染，亦用于MRSA感染；口服治疗难辨梭状芽孢杆菌所致伪膜性肠炎有良效；与其他抗葡萄球菌药物联用减少耐药性产生。
相关属性
基本信息物化属性
1,1'-((1R,2R,3S,4R,5R,6S)-4-(((2R,3R,4R,5S)-3-(((2S,3S,4S,5R,6S)-4,5-二羟基-6-(羟甲基)-3-(甲基氨基)四氢-2H-吡喃-2-基)氧基)-4-甲酰基-4-羟基-5-甲基四氢呋喃-2-基)氧基)-2,5,6-三羟基环己烷-1,3-二基)双胍硫酸盐(2:3)
英文名称
1,1'-((1R,2R,3S,4R,5R,6S)-4-(((2R,3R,4R,5S)-3-(((2S,3S,4S,5R,6S)-4,5-Dihydroxy-6-(hydroxymethyl)-3-(methylamino)tetrahydro-2H-pyran-2-yl)oxy)-4-formyl-4-hydroxy-5-methyltetrahydrofuran-2-yl)oxy)-2,5,6-trihydroxycyclohexane-1,3-diyl)diguanidine sulfate(2:3)
CAS号
3810-74-0
分子式
C₄₂H₈₄N₁₄O₃₆S₃
分子量
1457.38
中文别名
硫酸链霉素; N,N'-[(1R,2R,3S,4R,5R,6S)-4-[[5-deoxy-2-O-[2-deoxy-2-(methylamino)-α-L-glucopyranosyl]-3-C-formyl-α-L-lyxofuranosyl]oxy]-2,5,6-trihydroxy-1,3-cyclohexanediyl]bis[guanidine] sulfate (2:3); O-2-deoxy-2-methylamino-α-L-glucopyranosyl-(1→2)-O-5-deoxy-3-C-formyl-α-L-lyxofuranosyl-(1→4)-N1,N3-diamidino-D-streptamine sulfate (2:3) (salt); MFCD00037023; Streptomycin sulfate salt; Streptomycin Sulfate; EINECS 223-286-0; Streptomycin Sulphate; 1,1’-{1-D-(1,3,5/2,4,6)-4-[5-deoxy-2-O-(2-deoxy-2-methylamino-α-L-glucopyranosyl)-3-C-formyl-α-L-lyxofuranosyloxy]-2,5,6-trihydroxycyclohex-1,3-ylene}diguanidine sulfate (2:3) (salt); Streptomycin (sulfate)
用途
化学合成；生命科学；沉淀核酸和抑制蛋白质生物合成；制药，用于结核、布氏及非溶血性链球杆菌所致感染性心内膜炎、鼠疫与兔热病、流感杆菌和革兰阴性杆菌感染的治疗。硫酸链霉素是链霉素的硫酸盐形式，系由土壤中放线菌属灰色链丝菌产生的抗生素，主要用于治疗结核杆菌所致的肺结核、骨结核等及敏感菌株所致的感染，也用于农用防治作物细菌性病害。
相关属性
基本信息物化属性
1,1'-((1R,2R,3S,4R,5R,6S)-4-(((2R,3R,4R,5S)-3-(((2S,3S,4S,5R,6S)-4,5-二羟基-6-(羟甲基)-3-(甲胺基)四氢-2H-吡喃-2-基)氧基)-4-羟基-4-(羟甲基)-5-甲基四氢呋喃-2-基)氧基)-2,5,6-三羟基环己烷-1,3-二基)二胍倍半硫酸盐
英文名称
1,1'-((1R,2R,3S,4R,5R,6S)-4-(((2R,3R,4R,5S)-3-(((2S,3S,4S,5R,6S)-4,5-Dihydroxy-6-(hydroxymethyl)-3-(methylamino)tetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-4-(hydroxymethyl)-5-methyltetrahydrofuran-2-yl)oxy)-2,5,6-trihydroxycyclohexane-1,3-diyl)diguanidine sesquisulfate
CAS号
5490-27-7
分子式
C₄₂H₈₈N₁₄O₃₆S₃
分子量
1461.42
中文别名
硫酸双氢链霉素; guanidine, N,N'''-[(1R,2R,3S,4R,5R,6S)-4-[[5-deoxy-2-O-[2-deoxy-2-(methylamino)-α-L-glucopyranosyl]-3-C-(hydroxymethyl)-α-L-lyxofuranosyl]oxy]-2,5,6-trihydroxy-1,3-cyclohexanediyl]bis-, sulfate (1:1) (salt); Dihydrostreptomycin sulfate; Guanidine, N'',N'''''-[(1R,2R,3S,4R,5R,6S)-4-[[5-deoxy-2-O-[2-deoxy-2-(methylamino)-α-L-glucopyranosyl]-3-C-(hydroxymethyl)-α-L-lyxofuranosyl]oxy]-2,5,6-trihydroxy-1,3-cyclohexanediyl]bis-, su lfate (1:1) (salt); 2,2'-[(1R,2R,3S,4R,5R,6S)-4-({5-Deoxy-2-O-[2-deoxy-2-(methylamino)-α-L-glucopyranosyl]-3-C-(hydroxymethyl)-α-L-lyxofuranosyl}oxy)-2,5,6-trihydroxy-1,3-cyclohexanediyl]diguanidine sulfate (1:1); 1,1'-[(1R,2R,3S,4R,5R,6S)-4-({5-Deoxy-2-O-[2-deoxy-2-(methylamino)-α-L-glucopyranosyl]-3-C-(hydroxymethyl)-α-L-lyxofuranosyl}oxy)-2,5,6-trihydroxycyclohexane-1,3-diyl]diguanidine sulfate (1:1)
用途
属抗生素类药，主要用于固紫染色阴性杆菌感染，也可用于结核杆菌感染；在牛、猪和羊中治疗细菌性疾病。
相关属性
基本信息物化属性
1,4-丁烷磺内酰胺
英文名称
1,2-Thiazinane 1,1-dioxide
CAS号
37441-50-2
分子式
C₄H₉NO₂S
分子量
135.18
中文别名
1,4-丁烷磺内酰胺; thiazinane 1,1-dioxide
用途
作为医药中间体，用于后续化学反应（如WO2004/111022专利中提及的合成步骤）。
相关属性
基本信息物化属性
1-(((6R,7R)-7-氨基-2-羧基-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-3-基)甲基)-1-甲基吡咯烷-1-鎓氯化物
英文名称
1-(((6R,7R)-7-Amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl)-1-methylpyrrolidin-1-ium chloride
CAS号
103121-85-3
分子式
C₁₃H₂₀ClN₃O₃S
分子量
333.83
中文别名
1-{[(6R,7R)-7-氨基-2-羧基-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-3-基]甲基}-1-甲基吡咯烷-1-鎓氯化物; 1-{[(6R,7R)-7-Amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-1-methylpyrrolidin-1-ium chloride; Cefepime Related Compound E
用途
医药分析标准。
相关属性
基本信息物化属性
1-乙酰氧基乙基 (6R,7R)-3-((氨基甲酰氧基)甲基)-7-((Z)-2-(呋喃-2-基)-2-(甲氧亚氨基)乙酰氨基)-8-氧代-5-硫代-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸酯
英文名称
1-Acetoxyethyl (6R,7R)-3-((carbamoyloxy)methyl)-7-((Z)-2-(furan-2-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
CAS号
64544-07-6
分子式
C₂₀H₂₂N₄O₁₀S
分子量
510.47
中文别名
Cefuroxime axetil; Ceftin; EINECS 259-560-1; Cefuroxime axetil; cefuroxime 1-acetoxyethyl ester; Zinat; UNII:Z49QDT0J8Z; 1-Acetoxyethyl (6R,7R)-3-[(carbamoyloxy)methyl]-7-{[(2Z)-2-(2-furyl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; 1-(acetyloxy)ethyl (6R,7R)-3-[(carbamoyloxy)methyl]-7-{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; Zinnat; Cetoxil; MFCD00864889; Cefuroximeaxetil
用途
头孢呋辛酯是头孢呋辛的前体药物，口服后经酯酶水解为头孢呋辛，抑制细菌细胞壁合成，对革兰阳性菌、革兰阴性菌及厌氧菌有抗菌作用，临床用于呼吸道、泌尿道、皮肤软组织等感染及淋球菌感染。
相关属性
基本信息物化属性
1-甘露糖野尻霉素盐酸盐
英文名称
1-Deoxymannojirimycin hydrochloride
CAS号
73465-43-7
分子式
C₆H₁₄ClNO₄
分子量
199.63
中文别名
1-甘露糖野尻霉素盐酸盐;1-脱氧麦诺吉利霉素;(2R,3R,4R,5R)-2-(羟甲基)-3,4,5-哌啶三醇盐酸盐;1-脱氧甘露聚霉素盐酸盐;盐酸脱氧曼诺尻霉素;1-脱氧甘露尻霉素盐酸盐;1-甘露糖野尻霉素盐酸盐 73465-43-7;1-Deoxymannojirimycin hydrochloride #天然产物 HY-W009783; DMJ;DMJ, HYDROCHLORIDE;DMM;DEOXYMANNOJIRIMYCIN HCL;DEOXYMANNOJIRIMYCIN, HYDROCHLORIDE;DEOXYMANNONOJIRIMYCIN HCL;1,5-DIDEOXY-1,5-IMINO-D-MANNITOL, HCL;1,5-DIDEOXY-1,5-IMINO-D-MANNITOL HYDROCHLORIDE
用途
1-甘露糖野尻霉素盐酸盐是一种选择性的I类α1,2-甘露糖苷酶抑制剂，IC50为20μM；也是一种N-联糖基化抑制剂，可抑制HIV-1毒株，具有抗病毒活性。
相关属性
基本信息物化属性
2,2'-((3S,6S,9R,15S,18R,21S,24S,30S,31R)-30-((S)-2-((R)-4-氨基-2-((S)-2-癸酰胺基-3-(1H-吲哚-3-基)丙酰胺基)-4-氧代丁酰胺基)-3-羧基丙酰胺基)-3-(2-(2-氨基苯基)-2-氧代乙基)-24-(3-氨基丙基)-6-((R)-1-羧基丙烷-2-基)-9-(羟甲基)-18,31-二甲基-2,5,8,11,14,17,20,23,26,29-十氧代-1-氧杂-4,7,10,13,16,19,22,25,28-九氮杂环三十一烷-15,21-二基)二乙酸
英文名称
2,2'-((3S,6S,9R,15S,18R,21S,24S,30S,31R)-30-((S)-2-((R)-4-Amino-2-((S)-2-decanamido-3-(1H-indol-3-yl)propanamido)-4-oxobutanamido)-3-carboxypropanamido)-3-(2-(2-aminophenyl)-2-oxoethyl)-24-(3-aminopropyl)-6-((R)-1-carboxypropan-2-yl)-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontane-15,21-diyl)diacetic acid
CAS号
103060-53-3
分子式
C₇₂H₁₀₁N₁₇O₂₆
分子量
1620.67
中文别名
Daptomycin; N-decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(1R)-2-carboxy-1-methylethyl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]-L-α-asparagine; N-Decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]-L-α-asparagine; N-Decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxy-2-propanyl]-9-(hydroxymethyl); -18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]-L-α-asparagine; Daptomycin; Deptomycin; Cubicin; (3S)-3-{[(2S)-4-amino-2-{[(2S)-2-(decanoylamino)-3-(1H-indol-3-yl)propanoyl]amino}-4-oxobutanoyl]amino}-4-{[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(1R)-2-carboxy-1-methylethyl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]amino}-4-oxobutanoic acid; Daptomycin,N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L-α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R)-3-methyl-L-α-glutamyl-α,2-diamino-γ-oxo-benzenebutanoicacid(13-4)lactone; LY146032; CUBICIN DAPTOMYCIN; Cidecin
用途
作为抗生素，用于治疗严重皮肤感染、复杂性皮肤和软组织感染、感染性心内膜炎、菌血症等革兰阳性菌感染；对耐药菌株（如MRSA、万古霉素耐药肠球菌）有效；还用于医药中间体合成。
相关属性
基本信息物化属性
2-((4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-(((2R,3R,4R,5S,6R)-5-(((2S,4R,5S,6S)-4,5-二羟基-4,6-二甲基四氢-2H-吡喃-2-基)氧基)-4-(二甲基氨基)-3-羟基-6-甲基四氢-2H-吡喃-2-基)氧基-16-乙基-4-羟基-15-((((2R,3R,4R,5R,6R)-5-羟基-3,4-二甲氧基-6-甲基四氢-2H-吡喃-2-基)氧基)甲基)-5,9,13-三甲基-2,10-二氧杂氧杂环十六烷-11,13-二烯-7-基)乙醛
英文名称
2-((4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-(((2R,3R,4R,5S,6R)-5-(((2S,4R,5S,6S)-4,5-Dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-16-ethyl-4-hydroxy-15-((((2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)-5,9,13-trimethyl-2,10-dioxooxacyclohexadeca-11,13-dien-7-yl)acetaldehyde
CAS号
1401-69-0
分子式
C₄₆H₇₇NO₁₇
分子量
916.1
中文别名
系统适用性试验用泰乐菌素; EINECS 215-754-8; Tylan 100; Vetil(R); Vetil; tylocine; TYLOCINE(R); Tylosine; TYLAN50; fradizine; Tylon; Tylosin,predominantly Tylosin A; TYLOSIN
用途
生命科学；组织培养基；一种兽用大环内酯类抗生素抗菌药。
相关属性
基本信息物化属性
2-(二乙氨基)乙基 4-氨基苯甲酸酯 (2S,5R,6R)-3,3-二甲基-7-氧代-6-(2-苯基乙酰胺基)-4-硫杂-1-氮杂双环[3.2.0]庚烷-2-羧酸盐水合物
英文名称
2-(Diethylamino)ethyl 4-aminobenzoate (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydrate
CAS号
6130-64-9
分子式
C₂₉H₄₀N₄O₇S
分子量
588.72
中文别名
Procaine Penicillin G Hydrate; Procaine penicilline G hydrate; MFCD00150771
用途
医药领域的抗生素；是由青霉素G与普鲁卡因经化学方法结合形成的结晶复合物
相关属性
基本信息物化属性
2-氧代-2-((2S,4S)-2,5,12-三羟基-4-(((2R,4S,5S,6S)-5-羟基-6-甲基-4-(2,2,2-三氟乙酰氨基)四氢-2H-吡喃-2-基)氧基)-7-甲氧基-6,11-二氧代-1,2,3,4,6,11-六氢并四苯-2-基)乙基戊酸酯
英文名称
2-oxo-2-((2S,4S)-2,5,12-trihydroxy-4-(((2R,4S,5S,6S)-5-hydroxy-6-methyl-4-(2,2,2-trifluoroacetamido)tetrahydro-2H-pyran-2-yl)oxy)-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)ethyl pentanoate
CAS号
56124-62-0
分子式
C₃₄H₃₆F₃NO₁₃
分子量
723.64
中文别名
Valrubicin; 2-Oxo-2-[(2S,4S)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-({2,3,6-trideoxy-3-[(trifluoroacetyl)amino]-α-L-lyxo-hexopyranosyl}oxy)-1,2,3,4,6,11-hexahydro-2-tetracenyl]ethyl valerate; Valrubicin; 2-oxo-2-[(2S,4S)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-({2,3,6-trideoxy-3-[(trifluoroacetyl)amino]-α-L-lyxo-hexopyranosyl}oxy)-1,2,3,4,6,11-hexahydrotetracen-2-yl]ethyl pentanoate; Vinorelbine (BICINS ); N-trifluoroacetyladriamycin-14-valerate; Pentanoic acid, 2-[(2S,4S)-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-[[2,3,6-trideoxy-3-[(2,2,2-trifluoroacetyl)amino]-α-L-lyxo-hexopyranosyl]oxy]-2-naphthacenyl]-2-oxoethyl ester; trifluoroacetyl-adriamyci14-valerate; N-(trifluoroacetyl)adriamycin 14-valerate (AD 32); 2-Oxo-2-[(2S,4S)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-({2,3,6-trideoxy-3-[(trifluoroacetyl)amino]-α-L-lyxo-hexopyranosyl}oxy)-1,2,3,4,6,11-hexahydrotetracen-2-yl]ethyl valerate; N-Trifluoroacetyldoxorubicin 14-valerate; ad32; N-Trifluoroacetyladriamycin 14-valerate; Valstar; (2S-cis)-Pentanoic Acid 2-(1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-((2,3,6-trideoxy-3-((trifluoroacetyl)amino)-a-L-lyxo-hexopyranosyl)oxy)-2-naphthacenyl)-2-oxoethyl Ester; N-trifluoroacetyldoxorubicin-14-valerate; antibioticad32
用途
化学合成；作为蒽环类化疗药物，用于治疗难治性膀胱原位癌；通过干扰正常DNA的分裂重组影响细胞生物学功能，干涉核酸代谢，抑制核苷形成核酸，引起大量染色体损伤并使细胞周期停止于G2期；可抑制TPA-和PDBu-诱导的PKC活化，IC50值分别为0.85μM和1.25μM；在抗鳞状细胞癌（SCC）细胞系集落形成实验中显示细胞毒性活性；与放射治疗联用可增强细胞毒作用；可减少仓鼠肿瘤生长；可减少小鼠急性炎症模型中浸润的中性粒细胞数量并降低炎症细胞因子表达水平
相关属性
基本信息物化属性
2-氨基-2-(羟甲基)丙烷-1,3-二醇 ((2R,3S)-3-甲基环氧乙烷-2-基)膦酸盐
英文名称
2-Amino-2-(hydroxymethyl)propane-1,3-diol ((2R,3S)-3-methyloxiran-2-yl)phosphonate
CAS号
78964-85-9
分子式
C₇H₁₈NO₇P
分子量
259.19
中文别名
试剂Fosfomycin Tromethamine(储存“2-8℃”；运输“常温”); mono(2-ammonium-2-hydroxymethyl-1,3-propanediol) (2R,cis)-1,2-epoxypropyl-phosphonate; acide [(2R,3S)-3-méthyloxiran-2-yl]phosphonique - 2-amino-2-(hydroxyméthyl)propane-1,3-diol (1:1); [(2R,3S)-3-Methyloxiran-2-yl]phosphonsäure--2-amino-2-(hydroxymethyl)propan-1,3-diol(1:1); methyl)-1,3-propanediol(1:1); (2R-cis)-(3-Methyloxiranyl)phosphonic Acid Compound with 2-Amino-2-(hydroxymethyl)propane-1,3-diol (1:1); Phosphonic acid, [(2R,3S)-3-methyloxiranyl]-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1); fosfomycintrometamolsalt; FosfoMycin troMethaMine API; [(2R,3S)-3-Methyl-2-oxiranyl]phosphonic acid - 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1); Tromethamine fosfosmycin; tromethamine-fosfomycin; (1R,2S)-(1,2-Epoxypropyl)phosphonic Acid Compound with 2-Amino-2-(hydroxymethyl)-1,3-propanediol (1:1); FOSFOMYCIN TROMETHAMOL; monuril; z1282; FOSFOMYCIN TROMETAMOL; [(2R,3S)-3-Methyloxiran-2-yl]phosphonic acid - 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:1); 1,3-Dihydroxy-2-(hydroxymethyl)propan-2-aminium hydrogen [(2R,3S)-3-methyloxiran-2-yl]phosphonate
用途
生命科学；抗生素类药，通过阻止细菌细胞壁的合成而起杀菌作用，对革半氏阳性及阴性菌都有效。主要用于金葡菌，大砀杆菌，奇异变形杆菌，痢疾杆菌等感染。
相关属性
基本信息物化属性
21-羟基霉素A
英文名称
21-Hydroxyoligomycin A
CAS号
102042-09-1
分子式
C₄₅H₇₄O₁₂
分子量
807.06
中文别名
21羟基寡霉素A;羟寡霉素A,21-;21-羟基霉素A;寡霉素杂质7 (21-羟基寡霉素A); 21-Hydroxyoligomycin A;(1R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22S,23R,25S,27R,28S,29R)-22-ethyl-7,11,14,15,23-pentahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethylspiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-oxane]-3,9,13-trione;(1R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22S,23R,25S,27R,28S,29R)-22-ethyl-7,11,14,15,23-pentahydroxy-6'-((2R)-2-hydroxypropyl)-5',6,8,10,12,14,16,28,29-nonamethylspiro(2,26-dioxabicyclo(23.3.1)nonacosa-4,18,20-triene-27,2'-oxane)-3,9,13-trione;RefChem:89658;21-hydroxyl-oligomycin A;21-Hydroxy-Oligomycin;CHEBI:198978;Q27459825;(1R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22S,23R,25S,27R,28S,29R)-22-ethyl-7,11,14,15,23-pentahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-3',4',5',6'-tetrahydro-3H,9H,13H-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-pyran]-3,9,13-trione
用途
21-羟基霉素A是一种K-Ras PM定位的有效抑制剂，IC50值为4.82 nM，具有细胞毒性，可从Streptomyces中分离得到，用于相关医药研究。
相关属性
基本信息物化属性
3-(((4-甲基-1-哌嗪基)亚氨基)甲基)-rifomycins
英文名称
8-(n-(4-methyl-1-piperazinyl)formidoyl)-rifomycins
CAS号
13292-46-1
分子式
C₄₃H₅₈N₄O₁₂
分子量
822.94
中文别名
利福平; (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-Pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-{(E)-[(4-methyl-1-piperazinyl)imino]methyl}-6,23-dioxo-8,30-dioxa-24-azatetracyc ;lo[23.3.1.1.0]triaconta-1(28),2,4,9,19,21,25(29),26-octaen-13-yl acetate; rifobac; Rimactane; arficin; Rifampicin; FaMcin; rifinah; Eremfat; Rimactan; rifagen; MFCD00151389; Rifamycin AMP; 3-[[(4-Methyl-1-piperazinyl)imino]methyl]rifamycin; Rifadine; RIF; 3-(4-Methylpiperazinyliminomethyl)rifamycin SV,Rifampin,Rifamycin AMP; (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-Pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-{(E)-[(4-methyl-1-piperazinyl)imino]methyl}-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1.0]triaconta-1(28),2,4,9,19,21,25(29),26-octaen-13-yl acetate; (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E)-2,15,17,27,29-Pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-{(E)-[(4-methylpiperazin-1-yl)imino]methyl}-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1.0]triaconta-1(28),2,4,9,19,21,25(29),26-octaen-13-yl acetate; Rifa; (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-{(E)-[(4-methylpiperazin-1-yl)imino]methyl}-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1.0]triaconta-1(28),1(29),2,4,9,19,21,25,27-nonaen-13-yl acetate; UNII-VJT6J7R4TR; (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-Pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-{(E)-[(4-methylpiperazin-1-yl)imino]methyl}-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1.0]triaconta-1(28),2,4,9,19,21,25(29),26-octaen-13-yl acetate; EINECS 236-312-0; (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-Pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-{(E)-[(4-methylpiperazin-1-yl)imino]methyl}-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1.0]triaconta-1(28),1(29),2,4,9,19,21,25,27-nonaen-13-ylacetat; (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-{(E)-[(4-methylpiperazin-1-yl)imino]methyl}-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate; Abrifam; Rifampin; RIFADIN
用途
生命科学领域用于化学修饰利福霉素分子；医药领域作为抗生素；是细菌核糖核酸聚合酶的特殊抑制剂。
相关属性
基本信息物化属性
3-羟基头孢
英文名称
3-Hydroxycephem
CAS号
54639-48-4
分子式
C₂₈H₂₄N₂O₅S
分子量
500.57
中文别名
(6R,7R)-3-羟基-8-氧代-7-[(苯基乙酰基)氨基]-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸二苯基甲酯;NUCLEUS OF CEFTAROLINE FOSAMIL 头孢洛林酯母核;3-羟基头孢 3-OH;三羟基头孢;GHYA头孢唑肟钠中间体;头孢唑肟钠中间体;7-苯乙酰氨基-3-羟基-3-头孢环-4-羧酸二苯甲酯;3-羟基头孢或 7-苯乙酰氨基-3-羟基-3-头孢环-4-羧酸二苯甲酯; GHYH (7-PHENYLACETAMIDE-3-HYDROXY-3-CEPHEM-4-CARBOXYLIC ACIDDIPHENYLMETHYL ESTER);(6R,7R)-Benzhydryl 3-hydroxy-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-ca;Benzhydryl (6R,7R)-3-hydroxy-8-oxo-7-[(2-phenylacetyl)aMino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;(6R,7R)-Benzhydryl 3-hydroxy-8-oxo-7-(2-phenylacetaMido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;3-hydroxy cephalosporin;7-Phenyl acetylamino-3-hydroxy-3-cephemcyclo-4- carboxylic acid diphenyl methyl ester(3-OH);7-Phenylacetamide-3-Hydroxy-3-cephem-4-;3- hydroxy group
用途
化学合成，医药头孢唑肟钠中间体；头孢唑肟钠中间体，亦可作头孢母核，各类头孢中间体。
相关属性
基本信息物化属性
4-Epianhydrochlortetracycline Hydrochloride
英文名称
4-Epianhydrochlortetracycline Hydrochloride
CAS号
158018-53-2
分子式
C₂₂H₂₂Cl₂N₂O₇
分子量
497.33
中文别名
4-Epianhydrochlortetracycline Hydrochloride; 4-Epianhydrochlortetracycline HCl; 4-Epianhydrochlortetracycline Hydrochloride
用途

相关属性
基本信息物化属性
4-epi-Chlortetracycline Hydrochloride
英文名称
4-Epichlortetracycline hydrochloride
CAS号
101342-45-4
分子式
C₂₂H₂₄Cl₂N₂O₈
分子量
515.34
中文别名
4-epi-Chlortetracycline Hydrochloride; 4-Epichlortetracycline Hydrochloride; 4-epi-Chlortetracycline Hydrochloride; 4-epi-Chlortetracycline (hydrochloride); (4R,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide; hydrochloride; 4-epi-Chlortetracycline Hydrochloride (>90%); C22H24Cl2N2O8; MFCD09842537; 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, hydrochloride (1:1), (4R,4aS,5aS,6S,12aS)-; 4-epi-Chlortetracycline Hydrochloride (>90% by HPLC); EA87X68ELD; MSK4118A; orb1693596; orb3026001; 4-Epichlortetracycline hydrochloride; Epichlortetracycline hydrochloride; CHEMBL1950580; QYAPHLRPFNSDNH-QNUQNERCSA-N; 4-epichlortetracycline hydro-chloride; AKOS024306930; AE22723; PD017966; ST50307319; T36595; 4-Epichlortetracycline hydrochloride 100 microg/mL in Acetonitrile:Water; (4r,4as,5as,6s,12as)-7-chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride; (6S,12aS,4aS,5aS,4R)-4-(dimethylamino)-7-chloro-3,6,10,12,12a-pentahydroxy-6-m ethyl-1,11-dioxo-4,5,6,12a,4a,5a-hexahydronaphthacene-2-carboxamide, chloride; 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, (4R,4aS,5aS,6S,12aS)-; 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, [4R-(4alpha,4abeta,5abeta,6alpha,12abeta)]-; 7-chloro-4-dimethylamino-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide hydrochloride
用途
生命科学。
相关属性
基本信息物化属性
4-差向脱水四环素
英文名称
4-EPI-ANHYDROTETRACYCLINE HYDROCHLORIDE
CAS号
4465-65-0
分子式
C₂₂H₂₃ClN₂O₇
分子量
462.88
中文别名
差向脱水四环素;(4R,4AS,12AS)-4-(二甲氨基)-1,4,4A,5,12,12A-六氢-3,10,11,12A-四羟基-6-甲基-1,12-二氧代-2-并四苯甲酰胺单盐酸盐;4-差向脱水四环素盐酸盐;差向脱水四环素盐酸盐;差向脱水四环素盐酸盐溶液, 100PPM;4-差向脱水四环素盐酸盐标准品;4-差向脱水四环素;4-差向脱水四环素 USP标准品; 4-epianhydrotetracyclinehydrochloride’canbeusedassecondarystandard’;4-EPI-ANHYDROTETRACYCLINE HYDROCHLORIDE;Lymecycline Impurity 4（Lymecycline EP Impurity D）;Tetracycline EP Impurity D HCl;(4R,4AS,12AS)-4-(DIMETHYLAMINO)-1,4,4A,5,12,12A-HEXAHYDRO-3,10,11,12A-TETRAHYDROXY-6-METHYL-1,12-DIOXO-2-NAPHTHACENECARBOXAMIDE MONOHYDROCHLORIDE;4-Epianhydrotetracycline hydrochloride, 'can be used as a secondary standard', 97%;4-Epianhydroustetracycline hydrochloride;4-Epianhydrotetracycline hydrochloride,97%,'can be used as a secondary standard'
用途
生物活性 4-Epianhydrotetracycline hydrochloride 是抗生素 Tetracycline 的降解产物。4-Epianhydrotetracycline hydrochloride 对 Pseudomonas，Agrobacterium，Moraxella，Bacillus 和 E. coli 具有活性 (MIC50s = 0.75-16 mg/L)。
相关属性
基本信息物化属性
4-溴钙离子载体A23187
英文名称
4-Bromo-a23187
CAS号
76455-48-6
分子式
C₂₉H₃₆BrN₃O₆
分子量
602.52
中文别名
4-溴钙离子载体A23187; A23187, 4-Bromo- - CAS 76455-48-6 - Calbiochem; ANTIBIOTIC A-23187, 4-BROMO; CALCIMYCIN, 4-BROMO; 4-BROMO-A23187; 4-BROMO-ANTIBIOTIC; 4-BROMO-ANTIBIOTIC A23187; 4-BROMOCALCIMYCIN; 4-BROMOCALCIMYCIN A23187
用途
4-溴钙离子载体A23187是A-23187的卤代类似物，是一种高选择性钙离子载体，作为钙调节剂可诱导HL-60细胞等的凋亡
相关属性
基本信息物化属性
6-(1-甲-反-丙基-L-2-吡咯烷甲酰氨基)-1-硫代-6,8-二脱氧-D-赤式-α-D-半乳辛吡喃糖苷盐酸一水合物
英文名称
Lincocin Hydrochloride Monohydrate
CAS号
7179-49-9
分子式
C₁₈H₃₇ClN₂O₇S
分子量
461.014
中文别名
盐酸林可霉素一水合物;盐酸林可霉素(一水物);盐酸洁霉素一水合物;盐酸林可霉素; (2S-trans)-Methyl 6,8-Dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-D-erythro-a-D-galactooctopyranoside Monohydrochloride Monohydrate; Methyl (5R)-5-[(1R,2R)-2-hydroxy-1-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}propyl]-1-thio-β-L-arabinopyranoside hydrochloride hydrate; Lincomycin hydrochloride monohydrate; EINECS 212-726-7; Frademicina; MFCD00167245; Waynecomycin; mycivin; Cillimycin; Methyl 6,8-dideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-α-D-galacto-octopyranoside hydrochloride hydrate; D-erythro-α-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, hydrochloride, hydrate (1:1:1); Lincomix; Lincomycin, hydrochloride hydrate; Lincomycin (hydrochloride hydrate)
用途
- 生物活性 Lincomycin hydrochloride monohydrate 是窄谱抗生素, 具有与红霉素相似的效力, 对革兰氏阳性球菌具有很好的作用效果, 主要抑制细菌细胞蛋白质的合成。 - 体内研究 Lincomycin (25 and 50 mg/kg, intravenously) depresses neuromuscular transmission to a degree which depended on stimulation frequencies in the rabbit sciatic nerve-gastrocnemius muscle preparation. Animal Model: Adult albino New Zealand rabbits weighing 2.5-3.5 kg. Dosage: 25 and 50 mg/kg. Administration: Intravenously. Result: Depressed neuromuscular transmission. - 化学性质白色结晶性粉未，微臭，味苦。该药抗菌谱广，无过敏性，穿透力强，是髓炎等骨科病的首选抗菌药物。 - 与红霉素相似，对革兰氏阳性菌有强大的抗菌作用。 - 与红霉素相似，对革兰阳性菌有强大的抗菌作用
相关属性
基本信息物化属性

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