- 英文名称
- Bryostatin 1
- 分子式
- C47H68O17
- 分子量
- 905.03
- 中文别名
- (2Z,2'E)-2,2'-((1S,3S,7R,11S,12S,15S,17R,21R,23R,25S,E)-25-乙酰氧基-1,11,21-三羟基-17-((R)-1-羟乙基)-10,10,26,26-四甲基-12-((2E,4E)-辛-2,4-二烯酰氧基)-19-氧代-18,27,28,29-四氧杂四环[21.3.1.13,7.111,15]二十九烷-8-烯-5,13-二亚基)二乙酸二甲酯; 蛋白激酶C激活剂; BRYO 1; BRYOSTATIN; bryostatin1,0; bryostatine-1; (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-Acetoxy-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl (2E,4E)-2,4-octadienoate; (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1.1]nonacos-8-en-12-yl (2E,4E)-octa-2,4-dienoate; (26R)-Bryostatin 1; NSC-339555; 2,4-Octadienoic acid, (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-(1R)-1-hydroxyethyl-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo21.3.1.13,7.111,15nonacos-8-en
- 用途
- 化学合成；作为有效的中枢神经系统渗透性的PKC调节剂，具有抗癌、抗炎、神经保护、抗HIV-1感染的特性；以Ki值为8.07 nM和0.45 nM分别结合到分离的Munc13-1的C1域和全长的Munc13-1蛋白；可招募Munc13-1从细胞质到细胞膜，增加Munc13-1的表达水平，通过TLR4调节树突状细胞，影响免疫系统；腹腔注射可消除实验性自身免疫性脑脊髓炎的发作
