- 英文名称
- Zotarolimus
- 分子式
- C52H79N5O12
- 分子量
- 966.21
- 中文别名
- 咗他莫司; 唑他莫司; 佐他利莫司; 佐罗莫司; (42S)-42-Deoxy-42-(1H-tetrazol-1-yl)rapamycin; A 179578; ABT 578; ABT-578; A-179578; ABT578; A179578; CS-1162; Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-; (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-19,30-dimethoxy-12-{(2R)-1-[(1S,3R,4S)-3-methoxy-4-(1H-tetrazol-1-yl)cyclohexyl]-2-propanyl}-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-10,21-dimethoxy-3-{(2R)-1-[(1S,3R,4S)-3-methoxy-4-(1H-tetrazol-1-yl)cyclohexyl]propan-2-yl}-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
- 用途
- 作为雷帕霉素类似物，抑制FKBP-12结合（IC50 2.8nM）；体外抑制平滑肌细胞（IC50 2.9nM）、内皮细胞（IC50 2.6nM）及T细胞增殖（Con A诱导人T细胞IC50 7.0nM）；体内用于冠状动脉再狭窄猪模型（减少内膜增生），抑制佐剂DTH、EAE及心脏移植排斥反应（ED50分别为1.72、1.17、3.71mg/kg/天）。
