- 英文名称
- Rp-8-bromoguanosine 3',5'-cyclic monophosphorothioate sodium salt
- 分子式
- C10H10BrN5NaO6PS
- 分子量
- 462.15
- 中文别名
- 化合物 Rp-8-Br-cGMPS; 8-Br-Cgmps; Rp-8-BrcGMPS; (2R,5R)-2-(2-amino-8-bromopurin-9-yl)-5-(dihydroxyphosphinothioyloxymethyl)-2,5-dihydrofuran-3,4-diol; (R)-8-Bromoguanosine cyclic 3',5'-(hydrogen phosphorothioate); Guanosine, 8-bromo-, cyclic 3',5'-(hydrogen phosphorothioate), (R)-; O-{[(2R,5R)-5-(8-Bromo-2-imino-1,2-dihydro-9H-purin-9-yl)-3,4-dihydroxy-2,5-dihydrofuran-2-yl]methyl} dihydrogen phosphorothioate; O-{[5-(8-Bromo-2-imino-1,2-dihydro-9H-purin-9-yl)-3,4-dihydroxy-2,5-dihydrofuran-2-yl]methyl} dihydrogen phosphorothioate; GUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, 8-BROMO-, RP-ISOMER, SODIUM SALT; 8-BROMOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE, RP-ISOMER SODIUM SALT; 8-BROMOGUANOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT, RPISOMER; 8-BR-CGMPS NA, RP-ISOMER; RP-8-BR-CGMPS; 2-Amino-8-bromo-9-((2R,4aR,6R,7R,7aS)-7-hydroxy-2-mercapto-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-3,9-dihydro-6H-purin-6-one
- 用途
- Rp-8-Br-cGMPS (Rp-8-bromo-Cyclic GMPS) sodium salt is an effective Ca2+-ATPase activator. It is also an agonist of rod-shaped CNG channels and an inhibitor of PKG. It mediates cytoplasmic Ca2+ reduction by activating Ca2+-ATPase and subsequently removing Ca2+ from cells.
