- 英文名称
- 2-(2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione
- 分子式
- C22H22N2O3
- 分子量
- 362.42
- 中文别名
- 2-[2-氧代-2-(2,2,4-三甲基-3,4-二氢-2H-喹啉-1-基)-乙基]-异吲哚-1,3-二酮; 2-[2-氧代-2-(2,2,4-三甲基-3,4-二氢喹啉-1-基)乙基]异吲哚-1,3-二酮; 2-[2-氧代-2-(2,2,4-三甲基-3,4-二氢喹啉-1-基)乙基]异吲哚啉-1,3-二酮; ML-SA1; TRPML激动剂ML-SA1; 化合物ML SA1; 2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydro-1(2H)-quinolinyl)ethyl]-1H-isoindole-1,3(2H)-dione; ML-SA1; 2-[2-oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1-yl)ethyl]isoindole-1,3-dione; 2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione; 2-[2-oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1-yl)ethyl]isoindoline-1,3-dione; TRPML Agonist, ML-SA1
- 用途
- 作为选择性TRPML激动剂，通过促进溶酶体的酸化和蛋白酶活性，抑制登格病毒2(DENV2)和寨卡病毒(ZIKV)，其抗DENV2 RNA和ZIKV RNA的IC50值分别为8.3 μM和52.99 μM；可诱发自噬；用于广谱抗病毒研究
