- 英文名称
- 6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylic acid
- 分子式
- C5H6N2O3
- 分子量
- 142.11
- 中文别名
- 6-氧-1,4,5,6-四氢哌嗪-3-甲酸; 3-羧基哒嗪,1,4,5,6-四氢-6-氧代-; 1,4,5,6-四氢-6-氧代-3-羧基哒嗪; 6-羰基-1,4,5,6-四氢哌嗪-3-甲酸; 6-氧代-4,5-二氢-1H-哒嗪-3-羧酸; 1,4,5,6-四氢-6-氧哒嗪-3-羧酸; 1,4,5,6-四氢-6-氧代哒嗪-3-甲酸; 6-氧代-1,4,5,6-四氢哒嗪-3-甲酸; 6-OXO-1,4,5,6-TETRAHYDROPYRIDAZINE-3-CARBOXYLIC ACID; 6-OXO-4,5-DIHYDRO-PYRIDAZINE-3-CARBOXYLIC ACID; 1,4,5,6-Tetrahydro-6-oxo-3-pyridazinecarboxylic acid; 6-keto-4,5-dihydro-1H-pyridazine-3-carboxylic acid; 6-oxo-1,4,5,6-tetrahydro-pyridazine-3-carboxylic acid; 3-carboxy-6-oxo-1,4,5,6-tetrahydropyridazine; 3-oxo-2,3,4,5-tetrahydro-6-pyridazinic acid; 6-Oxo-1,4,5,6-tetrahydro-pyridazin-3-carbonsaeure; 6-carboxy-2,3,4,5-tetrahydropyridazine-3-one; 6-Oxo-1,4,5,6-tetrahydro-3-pyridazinecarboxylic acid; 1,4,5,6-Tetrahydro-6-Oxopyridazine-3-Carboxylic Acid; 6-oxo-1,4,5,6-tetrahydropyridazine-3-carbonic acid; 6-oxo-1,4,5-trihydropyridazine-3-carboxylic acid
- 用途
- - 6-氯哒嗪-3-羧酸甲酯它的化学和生物化学特性已使它成为抗肿瘤、抗病菌和农业杀虫剂等方面的重要药物和中间体，是制备硬脂酰CoA去饱和酶来治疗肥胖病的重要中间体。
- 制备
α-酮戊二酸 2.2g 加入到装有 5 mL 水的单口瓶中，室温搅拌下缓慢滴加 9 mL水合肼(3~4 min)，溶液慢慢变为淡黄色，搅拌30 min后放入冰箱中，3 h 后抽滤，得白色粉末2.07 g，产率 98.1 %。m.p. 265 ℃。直接用于下步反应。
