- 英文名称
- Nedocromil
- 分子式
- C19H17NO7
- 分子量
- 371.34
- 中文别名
- 来多克罗米; 萘多罗米; 奈多罗米; 9-乙基-6,9-二氢-4,6-二氧代-10-丙基-4H-吡喃并[3,2-G]喹啉-2,8-二羧酸; 9-乙基-6,9-二氢-4,6-二氧代-10-丙基-4H-吡喃并[3,2-G]喹啉-2,8-二甲酸; FPL-59002; FPL-59002KP; Rapitil; Tilade; 4H-Pyrano(3,2-G)quinoline-2,8-dicarboxylic acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-; 9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano(3,2-G)chinolin-2,8-dicarbonsaeure; Nedocromilo; Nedocromilum; 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano(3,2-g)quinoline-2,8-dicarboxylic acid; 9-ethyl-4,6-dioxo-10-propylpyrano[3,2-g]quinoline-2,8-dicarboxylic acid; 4,6-Dioxo-1-ethyl-10-propyl-4H,6H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid; Alocril
- 用途
- - 生物活性
Nedocromil 抑制多种介质的作用或形成，包括组胺，白三烯 C4 (LTC4) 和前列腺素 D2 (PGD2)。
- 靶点
LTC
4
PGD
2
Histamine
- 体外研究
Nedocromil inhibits the release of histamine, LTC
4
, and PGD
2
from mast cells challenged with antigen (with IC
30
values of 2.1 μM, 2.3 μM, and 1.9 μM, respectively) and with anti-human IgE (IC
30
values of 4.7 μM, 1.3 μM, and 1.3 μM, respectively).
- 体内研究
Nedocromil-treated diabetic mice show significantly improved heart function compared with controls. The contractility and relaxation forces show similar improvements. However, the cardiac function of Nedocromil-treated diabetic mice remains significantly impaired when compared with normal mice. Nedocromil can significantly improve cardiac function in mice with diabetic cardiomyopathy, but the treatment cannot restore normal function.
- 化学性质
黄色结晶性粉末。熔点298-300℃(分解)。
奈多罗米二钠盐(奈多罗米钠，Nedocromil Disodium)：C19H15NO7Na2。[69049-74-7]。淡黄色结晶性粉末。
- 哮喘预防药，须吸入给药。本品以原形排泄，不被代谢，因而长期使用不会产生蓄积作用。对可逆性气道阻塞性疾病，包括支气管哮喘、哮喘性支气管炎、新发作哮喘、劳力引起的哮喘等可作经常性预防治疗。
