- 英文名称
- Limaprost
- 分子式
- C22H36O5
- 分子量
- 380.52
- 中文别名
- (E)-7-((1R,2R,3R)-3-羟基-2-((3S,5S,E)-3-羟基-5-甲基壬-1-烯-1-基)-5-氧代环戊基)庚-2-烯酸; 利马司特; (2E,11Α,13E,15S,17S)-11,15-二羟基-17,20-二甲基-9-氧代前列-2,13-二烯-1-酸; 利马前列; 利马斯特; 立马前列素; (E)-7-((1R,2R,3R)-3-Hydroxy-2-((3S,5S,E)-3-hydroxy-5-methylnon-1-en-1-yl)-5-oxocyclopentyl)hept-2-enoic acid; (E)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S,5S)-3-hydroxy-5-methylnon-1-enyl]-5-oxocyclopentyl]hept-2-enoic acid; 17S,20-Dimethyl-trans-delta2-PGE1; (E)-7-((1R,2R,3R)-3-Hydroxy-2-((E)-(3S,5S)-3-hydroxy-5-methyl-1-nonenyl)-5-oxocyclopentyl)-2-heptenoic acid; (2E)-7-{(1R,2R,3R)-3-Hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methylnon-1-en-1-yl]-5-oxocyclopentyl}hept-2-enoic acid; 9-Oxo-11a,15a-dihydroxy-17S,20-dimethylprosta-trans-2,trans-13-dienoic Acid; 17S,20-Dimethyl-trans-2,3-didehydro-PGE1; (2E,11a,13E,15S,17S)-11,15-Dihydroxy-17,20-dimethyl-9-oxoprosta-2,13-dien-1-oic Acid; 17S-Methyl-w-homo-trans-D2-PGE1; ONO 1206; OP 1206; LIMAPROST; 2-Heptenoic acid, 7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonenyl]-5-oxocyclopentyl]-, (2E)- (9CI); Prosta-2,13-dien-1-oic acid, 11,15-dihydroxy-17,20-dimethyl-9-oxo-, (2E,11a,13E,15S,17S)-
- 用途
- 增加血流量并抑制血小板聚集；缓解疼痛，具有抗心绞痛作用，用于缺血性症状的研究；对末梢循环有改善作用，对血小板的环磷酸苷含量、血栓素的生成有抑制作用；用于闭塞性血栓血管炎及并发溃疡、疼痛及冷感等缺血症状；抑制IL-1介导的人IVD细胞中神经生长因子（NGF）的诱导，IC50为70.9nM；口服100mg/kg以上可缓解大鼠Argipressin诱导的心电图ST段压低；犬冠状动脉内注射1-100ng/kg可显著增加冠状动脉血流量，对心率、血压等无影响；静脉注射1-3mg/kg可降低犬冠状动脉大、小血管阻力；口服相同或更低剂量可抑制豚鼠ADP和胶原输注诱导的血小板聚集、黏附性、出血时间及血小板减少症。
