医药。- 生物活性：Fenoterol hydrobromide (Phenoterol)是fenoterol的氢溴酸盐，Fenoterol是β2 adrenoreceptor激动剂，具有支气管扩张活性。- 靶点：β2 adrenoreceptor。- 体外研究：Fenoterol (1 μM; pre-incubated 30 minutes) treatment reduces AICAR-induced AMPK activation, NF-κB activation and TNF-α release, and also significantly downregulates the elevated phosphorylation levels of AMPK. Fenoterol inhibits lipopolysaccharide (LPS)-induced AMPK activation and inflammatory cytokine production in THP-1 cells. Fenoterol is also a potent exosome biogenesis and/or secretion activator in PC cells. Western Blot Analysis：Cell Line: THP-1 cells stimulated with AICAR；Concentration: 1 μM；Incubation Time: Pre-incubated 30 minutes；Result: Significantly downregulated the elevated phosphorylation levels of AMPK. - 体内研究：Fenoterol (0.7 mg/kg; intraperitoneal injection; twice a day; for 3 weeks) treatment suppresses mechanical allodynia during chronic treatment. Animal Model: Male C57BL/6J mice (6 weeks old) with neuropathy；Dosage: 0.7 mg/kg；Administration: Intraperitoneal injection; twice a day; for 3 weeks；Result: Alleviated neuropathic allodynia during chronic treatment. - 校准仪器和装置；评价方法；工作标准；质量保证/质量控制
