(2E)-2-氰基-3-(3,4-二羟基苯基)-N-苯基-2-丙烯酰胺; 化合物AG-494; 酪氨酸激酶抑制剂 AG 494; 化合物AG 494; 2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-2-enamide; Tyrphostin 48; TYRPHOSTIN B48; (E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-PHENYL-2-PROPENAMIDE; ALPHA-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMIDE; A-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMAMIDE; A-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMIDE; AG 494; N-PHENYL-3,4-DIHYDROXYBENZYLIDENECYANOACETAMIDE; TYRPHOSTIN AG 494; AG-494; HMS3266B19; (2E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenylacrylamide
用途
- 生物活性
AG-494是EGFR受体自身磷酸化的抑制剂，IC50为1.2 μM。它抑制依赖于EGF的细胞生长，IC50为6 μM。
- 靶点
Target
Value
EGFR
(Cell-free assay)
1.2 μM
- 体外研究
In DHER-14 cells, AG 494 inhibits Cdk2 activation and EGF-dependent DNA synthesis.
AG-494 significantly prevents NF-kB activation in silica-stimulated cells, and also reduces NF-kB activation in H
2
O
2
-treated cells.
AG-494 (3-9 μM; 5-7 days) inhibits BMP9-induced ALP activity in a dose-dependent manner.
化合物SU1498; SU1498; AG 1498; Tyrphostin SU 1498; (E)-2-cyano-3-[4-hydroxy-3,5-di(propan-2-yl)phenyl]-N-(3-phenylpropyl)prop-2-enamide; SU 1498; SU-1498; Tyrphostin SU 1498; AG 1498; (2E)-2-cyano-3-[4-hydroxy-3,5-bis(1-methylethyl)phenyl]-N-(3-phenylpropyl)-2-propenamide; (E)-3-(3,5-diisopropyl-4-hydroxyphenyl)-2-[(3-phenyl-n-propyl)aminocarbonyl]acrylonitrile
