- 生物活性
HDAC8-IN-1 是一个 HDAC8 抑制剂，其 IC50 值为 27.2 nM。
- 靶点
HDAC8
27.2 nM (IC
50
)
- 体外研究
HDAC8-IN-1 is a HDAC8 inhibitor with an IC
50
of 27.2 nM in cancer cell lines. HDAC8-IN-1 (compound 22 d) shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5); HDAC8-IN-1 exhibits cytotoxicity against human lung CL1-5 cells without significant cytotoxicity for normal IMR-90 cells.
