- 英文名称
- 2-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate
- 分子式
- C10H15F6N6OP
- 分子量
- 380.23
- 中文别名
- HATU; N,N,N′,N′-四甲基-O-(7-氮杂苯并三唑-1-基)六氟磷酸脲; 2-(7-偶氮苯并三氮唑)-N,N,N',N'-四甲基脲六氟磷酸酯; 双(二甲基氨基)甲叉-三唑[4,5-B]吡啶3-氧化物,六氟磷酸盐; 2-(7-偶氮苯并三氮唑)-四甲基脲六氟磷酸酯; 2-(7-氮杂苯并三氮唑)-四甲基脲六氟磷酸盐; 2-(7-氮杂-1H-苯并三氮唑-1-基)-1,1,3,3-四甲基脲六氟磷酸酯; 2-(7-氮苯并三氮唑)-N,N,N’,N’-四甲基脲六氟磷酸酯; 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate; O-(7-AZABENZOTRIAZOL-1-YL)URONIUM HEXAFLUORO-PHOSPHATE; O-(7-AZABENZOTRIAZOLE-1-YL)-N,N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE; O-(7-AZABENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE; N,N,N',N'-TETRAMETHYL-O-(7-AZABENZOTRIAZOL-1-YL)URONIUM HEXAFLUOROPHOSPATE; 2-(7-Aza-1H-Benzotriazole-1-yl)-1,1,3,3-Tetramethyluronium Hexafluorophosphate; N,N,N',N'-Tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate; O-(7-Azabenzotriazol-1-yl)-N,N,N,N-tetramethyl uronium hexafluorophosphate; [dimethylamino(triazolo[4,5-b]pyridin-3-yloxy)methylidene]-dimethylazanium,hexafluorophosphate; N-[(Dimethylamino)(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)methylidene]-N-methylmethanaminium hexafluorophosphate; O-(7-Aza-1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; (Dimethylamino)-N,N-dimethyl(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)methaniminium hexafluorophosphate; N-[(Dimethylamino)(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methylmethanaminium hexafluorophosphate
- 用途
- 化学合成，通过固相合成制备N-芳基磺酰胺键合肽；作为多肽缩合试剂，应用于羧基与氨基合成肽键的反应，相对于其他类似缩合剂反应速度更快，不易消旋，利用HATU进行酰胺化反应条件温和，产率高，很多大位阻的缩合剂也能反应，广泛应用于合成各种医药中间体；肽偶联试剂；利用固相合成方法制备N-芳磺胺连接的多肽；最新研究表明，该偶联剂的晶体以及溶液结构是胍盐N-氧化物，而不是脲阳离子化合物；固相肽合成中有效的偶联剂。
