- 英文名称
- Levoleucovorin Calcium
- 分子式
- C20H21CaN7O7
- 分子量
- 511.51
- 中文别名
- (4-((((S)-2-氨基-5-甲酰基-4-氧代-1,4,5,6,7,8-六氢蝶呤-6-基)甲基)氨基)苯甲酰基)-L-谷氨酸钙盐(1:1); 亚叶酸钙; 左旋亚叶酸钙; 左旋亚叶本钙; 左旋甲酰四氢叶酸钙; 氢叶酸钙(左亚叶酸钙 ); (6S)-5-甲酰基-5,6,7,8-四氢叶酸,钙盐(天然钙叶酸钙); (4-((((S)-2-Amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamic acid, calcium salt(1:1); calcium,(2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate; folinic acid calcium salt; Levoleucovorin calcium (USAN); Calcium (2S)-2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydro-6-pteridinyl]methyl}amino)benzoyl]amino}pentanedioate; calcium levofolinate; Fusilev (TN); Calcium N-(p-((((6S)-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamate (1:1); Isovorin; Calcium 2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]amino}pentanedioate; Levofolinate calcium (JAN); Elvorine; Levoleucovorin (Calcium); N-[4-[[[(6S)-2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-L-glutamic Acid Calcium Salt (1:1); L-Glutamic acid, N-[4-[[[(6S)-2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-, calcium salt (1:1); Calcium levofolinate (INN); Levofolinate; calcium n-(4-(((2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-l-glutamate; (S)-Leucovorin calcium salt (1:1)
- 用途
- 左亚叶酸钙为抗肿瘤新药，主要用于治疗骨肉瘤经大剂量甲氨蝶呤治疗后与叶酸拮抗相关的症状；也可用来治疗叶酸缺乏引起的巨细胞贫血；还可和氟尿嘧啶联合使用来延长进展期结肠癌患者的生存期或缓解症状。用法用量为左亚叶酸钙100mg加入0.9%氯化钠注射液100ml中静脉点滴1小时，之后予以5-氟尿嘧啶375～425mg/㎡静脉点滴4～6小时。
