- 英文名称
- Ketorolac tromethamine
- 分子式
- C19H24N2O6
- 分子量
- 376.41
- 中文别名
- (+/-)-5-苯甲酰基-2,3-二氢-1H-吡咯里嗪-1-甲酸氨丁三醇盐; 辛太克斯(浮选剂); 安贺拉PF; 酮咯酸三醇; 酮咯酸氨三丁醇; 2-氨基-2-(羟甲基)丙烷-1,3-二醇 5-苯甲酰基-2,3-二氢-1H-吡咯里嗪-1-甲酸盐; KETOROLAC TRIS SALT; KETOROLAC TROMETHAMINE SALT; (+/-)-5-BENZOYL-2,3-DIHYDRO-1H-PYRROLIZINE-1-CARBOXYLIC ACID, TRIS (HYDROXYMETHYL) AMINOMETHANE SALT; (+/-)-5-benzoyl-2,3-dihydro-1h-pyrrolizine-1-carboxylic acid tris(hydroxymethyl)methylamine salt; (+/-)-5-BENZOYL-2,3-DIHYDRO-1H-PYRROLIZINE-1-CARBOXYLIC ACID TRIS SALT; KETROLAC TROMETHAMINE SALT; (±)-Form tromethamine salt; 2-amino-2-(hydroxymethyl)propane-1,3-diol,5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid; rac Ketorolac Tromethamine Salt; 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid - 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:1); 5-(phenylcarbonyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid - 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:1); 1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1); (±)-Ketorolac Tromethamine Salt; 5-(Phenylcarbonyl)-2,3-dihydro-1H-pyrrolizin-1-carbonsäure--2-amino-2-(hydroxymethyl)propan-1,3-diol(1:1); 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid - 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1); 1,3-Dihydroxy-2-(hydroxymethyl)propan-2-aminium 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate; Ketorolac (tromethamine salt)
- 用途
- 作为非甾体抗炎药（NSAID），具有消炎、止痛和退热活性，是一种非选择性COX抑制剂，对COX-1和COX-2的IC50值均为20 nM；在体内研究中，可抑制LPS内毒素诱导的前房FITC-葡聚糖增加及家兔房水PGE2浓度升高，能快速逆转大鼠痛觉过敏，减少角叉菜胶诱导的痛觉过敏和爪PG生成，降低大鼠PGE2水平，且对大鼠牙槽窝内骨小梁体积分数无不利影响，可减少缺血性细胞死亡等组织学改变，改善后肢运动功能并提高长期存活率。
