- 英文名称
- Trichostatin A
- 分子式
- C17H22N2O3
- 分子量
- 302.37
- 中文别名
- (R,2E,4E)-7-(4-(二甲氨基)苯基)-N-羟基-4,6-二甲基7-oxohepta-2,4-二烯酰胺; 曲古柳菌素A; 曲古抑菌素; 曲古柳菌素A(TSA); 曲古柳菌素-1; (R,2E,4E)-7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide; Antibiotic A-300; (2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide; (R)-Trichostatin A; 2,4-Heptadienamide, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)- (9CI); TSA; 7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide; 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6R-dimethyl-7-oxo-2E,4E-heptadienamide; 7-(4-(dimethylamino)phenyl)-n-hydroxy-4,6-dimethyl-7-oxo-4-heptadienamide; 4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXAHEPTA-2,4-DIENOHYDROXAMIC ACID; 4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXOHEPTA-2,4-DIENOHYDROXAMIC ACID; Trichostatin A from Streptomyces platensis; [r-(e,e)]-7-[4-(dimethylamino)phenyl]-n-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide; 7-(4-DIMETHYLAMINOPHENYL)-N-HYDROXY-4,6-DIMETHYL-7-OXO-HEPTA-2,4-DIENAMIDE
- 用途
- Trichostatin A (TSA)是一种HDAC抑制剂，无细胞试验中IC50为1.8 nM左右；抑制八种乳腺癌细胞系增殖，平均IC50为124.4 nM，抑制HDAC活性平均IC50为2.4 nM，产生组蛋白H4高度乙酰化，对HDAC1、HDAC4、HDAC6抑制程度相似；作用于MIA PaCa-2细胞可诱导转化生长因子βⅡ型受体表达；按0.5 mg/kg剂量处理大鼠乳腺癌模型有抗癌活性且无毒性，处理脊髓性肌萎缩症模型鼠可提高组蛋白乙酰化水平、促进存活及增强运动行为。
