- 英文名称
- Sonolisib
- 分子式
- C29H35NO8
- 分子量
- 525.59
- 中文别名
- PX 866; PX-866; PX866; Px 866; PX-866; PX866; DJM-166; DJM-2-166; [(3aR,6E,9S,9aR,10R,11aS)-6-[[bis(prop-2-enyl)amino]methylidene]-5-hydroxy-9-(methoxymethyl)-9a,11a-dimethyl-1,4,7-trioxo-2,3,3a,9,10,11-hexahydroindeno[4,5-h]isochromen-10-yl] acetate; (1E,4S,4aR,5R,6aS,9aR)-1-[(diprop-2-en-1-ylamino)methylidene]-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,7,10-trioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-5-yl acetate; (1E,4S,4aR,5R,6aS,9aR)-1-[(Diallylamino)methylene]-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,7,10-trioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-5-yl acetate; (1E,4S,4aR,5R,6aS,9aR)-5-(Acetyloxy)-1-[(di-2-propen-1-ylamino)methylene]-4,4a,5,6,6a,8,9,9a-octahydro-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-cyclopenta[5,6]naphtho[1,2-c]pyran-2,7,10(1H)-trione; (2R,3S,6Z,11R,15S,17R)-6-{[bis(prop-2-en-1-yl)aMino]Methylidene}-8-hydroxy-3-(MethoxyMethyl)-2,15-diMethyl-5,9,14-trioxo-4-oxatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-1(10),7-dien-17-yl acetate
- 用途
- 化学合成；作为PI3K抑制剂，用于治疗多形性成胶质细胞瘤、转移性前列腺癌(CRPC)、黑色素瘤、非小细胞肺癌、头颈癌等实体瘤；处于临床二期，用于治疗多形性成胶质细胞瘤和转移性前列腺癌(CRPC)，用于治疗黑色素瘤、非小细胞肺癌和头颈癌的研究处于临床一期和二期；是一种改良的Wortmannin类似物，可口服、不可逆、泛亚型的PI3K抑制剂，抑制PI3K/Akt信号通路，具有抗肿瘤活性
