- 英文名称
- Polymyxin B1
- 分子式
- C56H98N16O13
- 分子量
- 1203.48
- 中文别名
- 多粘菌素B1; (S)-N-((S)-4-氨基-1-(((2S,3R)-1-(((S)-4-氨基-1-氧代-1-(((3S,6S,9S,12S,15R,18S,21S)-6,9,18-三(2-氨基乙基)-15-苄基-3-((R)-1-羟乙基)-12-异丁基-2,5,8,11,14,17,20-七氧代-1,4,7,10,13,16,19-七氮杂环二十三烷-21-基)氨基)丁-2-基)氨基-3-羟基-1-氧代丁-2-基)氨基)-1-氧代丁-2-基)-6-甲基辛酰胺; polymyxin B; polymixin B1; polymyxin B1; (S)-N-((S)-4-Amino-1-(((2S,3R)-1-(((S)-4-amino-1-oxo-1-(((3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-((R)-1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl)amino)butan-2-yl)amino)-3-hydroxy-1-oxobutan-2-yl)amino)-1-oxobutan-2-yl)-6-methyloctanamide; (6S)-N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide
- 用途
- 生化研究；作为抗菌脂肽Polymyxin B1，用于多重耐药性革兰氏阴性菌感染研究，体外对Pseudomonas aeruginosa ATCC 27853等有抗菌活性，体内在大鼠模型中静脉给药0.8 mg/kg的药代动力学研究显示其AUC等参数优于colistins A和B
