- 英文名称
- NF279
- 分子式
- C49H30N6Na6O23S6
- 分子量
- 1401.12
- 中文别名
- 可溶性品红-279; 8,8'-[羰基双(亚氨基-4,1-亚苯基羰基亚氨基-4,1-亚苯基羰基亚氨基)]双-1,3,5-萘三磺酸钠盐; 化合物NF279; N-[4,6,8-tris(methylsulfonyl)naphthalen-1-yl]-4-[[4-[[4-[[4-[[4,6,8-tris(methylsulfonyl)naphthalen-1-yl]carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzamide; cc-368; 1,3,5-Naphthalenetrisulfonic acid, 8,8'-[carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-, sodium salt (1:6); Hexasodium 8-[(4-{[4-({[4-({4-[(4,6,8-trisulfonato-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl]carbamoyl}amino)benzoyl]amino}benzoyl)amino]naphthalene-1,3,5-trisulfonate; Hexasodium 8,8'-[carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]di(1,3,5-naphthalenetrisulfonate); hexasodium;8-[[4-[[4-[[4-[[4-[(4,6,8-trisulfonatonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonate; 1,3,5-Naphthalenetrisulfonic acid, 8,8'-[carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-, hexasodium salt; 8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic Acid Hexasodium Salt; 8,8'-(CARBONYLBIS(IMINO-4,1-PHENYLENECARBONYLIMINO-4,1-PHENYLENECARBONYLIMINO))BIS-1,3,5-NAPHTHALENETRISULFONIC ACID, NA; 8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalene-trisulphonic acid hexasodium salt
- 用途
- 化学合成；作为有效的选择性可逆P2X1受体拮抗剂（IC50 19 nM），对P2X2、P2X3（IC50=1.62 μM）、P2X4（IC50>300 μM）显示选择性；作为双重HIV-1共受体抑制剂，通过Env干扰CCR5和CXCR4的功能性结合。
