- 英文名称
- Eleutheroside B1
- 分子式
- C17H20O10
- 分子量
- 384.34
- 中文别名
- 刺五加皂苷B1; 6,8-二甲氧基-7-(((2R,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-2H-苯并吡喃-2-酮; eleutheroside B1; 2H-1-Benzopyran-2-one,7-(α-D-glucopyranosyloxy)-6,8-dimethoxy-; 6,8-Dimethoxy-7-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-one; Eleutheroside B 1; Eleutheroside B-1; 6,8-dimethoxy-7-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one; Eleutheroside-B1; Isofraxidin alpha-D-glucopyranoside; Isofraxidin 7-o-alpha-D-glucopyranoside; 7-(alpha-D-Glucopyranosyloxy)-6,8-dimethoxy-2H-1-benzopyran-2-one; ISOFRAXIDIN .ALPHA.-D-GLUCOPYRANOSIDE; ISOFRAXIDIN 7-O-.ALPHA.-D-GLUCOPYRANOSIDE; 7-(.ALPHA.-D-GLUCOPYRANOSYLOXY)-6,8-DIMETHOXY-2H-1-BENZOPYRAN-2-ONE; 6,8-dimethoxy-7-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxychromen-2-one; 6,8-dimethoxy-7-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-2H-chromen-2-one; 6,8-Dimethoxy-2-oxo-2H-1-benzopyran-7-yl alpha-D-glucopyranoside
- 用途
- 化学合成；作为Eleutheroside B1（香豆素化合物），具有广谱抗人流感病毒作用，IC50值64-125μg/ml，通过POLR2A和N-糖基化介导抗流感活性，抑制多种趋化因子基因和流感病毒核蛋白基因mRNA表达，细胞毒性低，具有抗病毒、抗炎活性；体外研究中，100μg/ml浓度处理24小时影响A549细胞中宿主基因（MAN2A2、POLR2A）和病毒基因（PA、PB1、PB2、HA）mRNA表达。
