- 英文名称
- Fumarate hydratase-IN-1
- 分子式
- C27H30N2O4
- 分子量
- 446.54
- 中文别名
- 富马酸水合酶-IN-1; Fumarate hydratase 抑制剂1; REL-(3S,3AR)-1-([1,1'-联苯基]-4-基甲基)-3-(2-(甲氨基)-2-氧代乙基)-2-氧代-1,2,3,4,5,6-六氢-3AH-吲哚-3A-羧酸乙酯; rel-Ethyl (3S,3aR)-1-([1,1'-biphenyl]-4-ylmethyl)-3-(2-(methylamino)-2-oxoethyl)-2-oxo-1,2,3,4,5,6-hexahydro-3aH-indole-3a-carboxylate; Ethyl (3S,3aR)-1-(4-biphenylylmethyl)-3-[2-(methylamino)-2-oxoethyl]-2-oxo-1,2,3,4,5,6-hexahydro-3aH-indole-3a-carboxylate; ethyl (3S,3aR)-3-[2-(methylamino)-2-oxoethyl]-2-oxo-1-[(4-phenylphenyl)methyl]-3,4,5,6-tetrahydroindole-3a-carboxylate; Fumarate hydratase inhibitor 1; 3aH-Indole-3a-carboxylic acid, 1-([1,1'-biphenyl]-4-ylmethyl)-1,2,3,4,5,6-hexahydro-3-[2-(methylamino)-2-oxoethyl]-2-oxo-, ethyl ester, (3R,3aS)-rel-
- 用途
- 作为细胞可渗透性的富马酸水合酶抑制剂，对多种细胞系（SW620、ACHN、HCT-116、PC3、SK-MEL-28）具有抗增殖活性，平均IC50为2.2 μM，靶点为富马酸水合酶。
