- 英文名称
- AS-19
- 分子式
- C18H25N3
- 分子量
- 283.41
- 中文别名
- 化合物AS19; 化合物T10380; (2S)-N,N-二甲基-5-(1,3,5-三甲基-4-吡唑基)-1,2,3,4-四氢萘-2-胺; AS19; AS 19; (2S)-(+)-5-(1,3,5-Trimethylpyrazol-4-YL)-2-(dimethylamino)tetralin; (2S)-N,N-Dimethyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydro-2-naphthalenamine; (2S)-N,N-Dimethyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydronaphthalen-2-amine; (S)-N,N-dimethyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydronaphthalen-2-amine; 2-Naphthalenamine, 1,2,3,4-tetrahydro-N,N-dimethyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-, (2S)-; (2S)-N,N-dimethyl-5-(1,3,5-trimethylpyrazol-4-yl)-1,2,3,4-tetrahydronaphthalen-2-amine; (2S)-1,2,3,4-Tetrahydro-N,N-dimethyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2-naphthalenamine; (2S)-N,N-dimethyl-5-(1,3,5-trimethylpyrazol-4-yl)tetralin-2-amine
- 用途
- 生命科学领域，作为选择性5-HT7受体激动剂，IC50 0.83 nM，Ki 0.6 nM，对5-HT1A、1B、1D、5A受体选择性高；体外可恢复对氯苯丙氨酸处理小鼠T细胞增殖；体内用于改善大鼠记忆巩固，剂量0.5-10 mg/kg皮下注射24小时。
