- 英文名称
- Phenserine
- 分子式
- C20H23N3O2
- 分子量
- 337.42
- 中文别名
- (3aS,8aR)-1,3a,8-三甲基-1,2,3,3a,8,8a-六氢吡咯并[2,3-b]吲哚-5-基 苯基氨基甲酸酯; 化合物Phenserine; 化合物T12446; Phenserine试剂; (3aS,8aR)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol 5-(N-phenylcarbamate); (3aS,8aR)-1,3a,8-Trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl phenylcarbamate; (-)-Phenserine; (-)-Eseroline phenylcarbamate; N-phenylcarbamoyleseroline; N-phenylcarbamoyl eseroline; (3aS-cis)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethyl-pyrrolo[2,3-b]indol-5-ol Phenylcarbamate (Ester); (-)-N-Phenylcarbamoyleseroline
- 用途
- Phenserine is a derivative of Physostigmine, an effective non-competitive, long-acting, and selective AChE inhibitor. It reduces β-amyloid precursor protein (APP) and β-amyloid peptide (Aβ) formation, improves cognitive ability, and alleviates Alzheimer's disease progression. In vitro: 1-25 μM for 48 hours in CHO APP 751SW cells shows 18.6% reduction at 10 μM and 51.4% reduction at 25 μM. In vivo: 1-4 mg/kg intraperitoneal injection for 4 days in male Fischer-344 rats improves learning and spatial memory in scopolamine-induced impairment.
