- 英文名称
- 5-(3-(4-Methoxyphenyl)allylidene)pyrimidine-2,4,6(1H,3H,5H)-trione
- 分子式
- C14H12N2O4
- 分子量
- 272.26
- 中文别名
- 5-[3-(4-甲氧基苯基)-2-丙烯-1-基]-2,4,6(1H,3H,5H)-嘧啶三酮; 5-(3-(4-甲氧基苯基)烯丙亚基)嘧啶-2,4,6(1H,3H,5H)-三酮; ML346; HSP70激动剂ML346; ML 346; ML-346; (E)-5-(3-(4-methoxyphenyl)allylidene)pyrimidine-2,4,6(1H,3H,5H)-trione; 5-[3-(4-methoxyphenyl)-2-propen-1-ylidene]-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-[(E)-3-(4-methoxyphenyl)prop-2-enylidene]-1,3-diazinane-2,4,6-trione; 5-[(2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]pyrimidine-2,4,6(1H,3H,5H)-trione; 5-[(2E)-3-(4-Methoxyphenyl)-2-propen-1-ylidene]-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-[(E)-3-(4-methoxyphenyl)prop-2-enylidene]hexahydropyrimidine-2,4,6-trione
- 用途
- 化学合成；作为Hsp70激活剂（ML346），体外可激活Hsp70（EC50 4600 nM），恢复蛋白质折叠、CFTR功能及细胞稳态，诱导Hsp70、HO1、GCLM等基因表达；体内可抑制线虫中polyQ35聚集，具有蛋白聚集及毒性修饰活性。
