- 英文名称
- (R)-(-)-Gossypol
- 分子式
- C30H30O8
- 分子量
- 518.55
- 中文别名
- (-)-棉子素; (R)-(-)-棉子酚; (R)-1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-[2,2'-binaphthalene]-8,8'-dicarbaldehyde; 1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl[2,2'-binaphthalene]-8,8'-dicarboxaldehyde; 1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-2,2'-binaphthalene-8,8'-dicarbaldehyde; 2,2'-Bis[1,6,7-trihydroxy-3-methyl-5-isopropyl-8-aldehydonaphthalene]; 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalene-8,8'-dicarbaldehyde; Gossypol; 2,2'-bis[8-formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene]; (-)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)[2,2'-binaphthalene]-8,8'-dicarboxaldehyde; 1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-2,2'-binaphthalen-8,8'-dicarbaldehyd; 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-2,2'-binaphthalene-8,8'-dicarbaldehyde; 1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)[2,2'-binaphthalene]-8,8'-dicarboxaldehyde; AT-101; (R)-Gossypol
- 用途
- (-)-棉子素易溶于乙醇、丙酮、三氯甲烷等有机溶剂及油脂，不溶于水；可作为男性节育药使用，醋酸棉子素口服制剂已上市，用于男用避孕或治疗子宫内膜异位症、月经过多或失调等妇科疾病；加入缓释材料形成缓释制剂可避免“峰谷”现象；(R)-(-)-Gossypol（AT-101）是天然棉子素的左旋异构体，能结合Bcl-2、Mcl-1和Bcl-xL蛋白，Ki值分别为260±30 nM、170±10 nM和480±40 nM；在体外研究中，AT-101对多种肿瘤细胞系有生长抑制和诱导凋亡作用，对正常细胞毒性较低
