- 英文名称
- Octreotide Acetate
- 分子式
- C51H70N10O12S2
- 分子量
- 1079.29
- 中文别名
- 奥曲肽; 奥曲肽乙酸盐; 醋酸奥曲酞; (4R,7S,10S,13R,16S,19R)-13-((1H-吲哚-3-基)甲基)-19-((R)-2-氨基-3-苯基丙酰胺基)-10-(4-氨基丁基)-16-苄基-N-((2R,3R)-1,3-二羟基丁-2-基)-7-((R)-1-羟乙基)-6,9,12,15,18-五氧代-1,2-二硫杂-5,8,11,14,17-五氮杂环二十烷-4-羧酰胺 x乙酸盐; Octreotide; Sandostatin; SMS 201-995; Sandostatin LAR; Sandostatin (TN); Octreotide acetate (USAN); 1,2-Dithia-5,8,11,14,17-pentaazacycloeicosane-4-carboxamide, 10-(4-aminobutyl)-19-[[(2R)-2-amino-1-oxo-3-phenylpropyl]amino]-7-(1-hydroxyethyl)-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-16-(phenylmethyl)-, (4R,7S,10S,13R,16S,19R)-, acetate (1:1) (salt); Octreotide (acetate); (4R,7S,10S,13R,16S,19R)-10-(4-Aminobutyl)-16-benzyl-N-[(2R,3R)-1,3-dihydroxy-2-butanyl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-19-(D-phenylalanylamino)-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide acetate (1:1); (4R,7S,10S,13R,16S,19R)-10-(4-Aminobutyl)-16-benzyl-N-[(2R,3R)-1,3-dihydroxy-2-butanyl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-19-(D-phenylalanylamino)-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide; (4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-19-(D-phenylalanylamino)-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide acetate (1:1); acetic acid,10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide; SMS-201-995; [r-(r*,r*)]-d-phenylalanyl-l-cysteinyl-l-phenylalanyl-d-tryptophyl-l-lysyl-l-threonyl-n-[2-hydroxy-1-(hydroxy-methyl)propyl]-cysteinamide cyclic(2->7)-disulfide; OCTREOTIDE (SMS 201-995), ACETATE; cyclic(2-7)-disulfide,(r-l-threonyl-n-(2-hydroxy-1-(hydroxymethyl)propyl); Octreotide (D-Phe5,Cys6·11,D-Trp8,L-Threoninol12)-SoMatostatin-14 (5-12), SMS-201-995; D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hydroxyMethyl)propyl]-
- 用途
- 消化系统用药，主要用于治疗门脉高压引起的食管静脉曲张出血、肢端巨大症、消化道出血（如肝硬化、食管静脉曲张出血、消化性溃疡出血和应激性溃疡出血）、胰腺疾病（如重型急性胰腺炎、胰损伤或手术后胰腺瘘），预防胰腺手术后并发症；还用于胃肠道瘘管，消化系内分泌肿瘤（如肠血管活性肽瘤、胃泌素瘤、胰高血糖素瘤、异位ACTH综合征、类癌综合征），肢端肥大症，突眼性甲亢症，全结肠切除后持续性、顽固性腹泻和艾滋病相关性腹泻；鞘内注射可治疗癌性疼痛。
