- 英文名称
- 4,6-O-Ethylidene-α-D-glucose
- 分子式
- C8H14O6
- 分子量
- 206.193
- 中文别名
- 4,6-O-亚乙基-α-D-葡萄糖;4,6-亚乙基-α-D-葡萄糖;4,6-亚乙基-alpha-D-葡萄糖; MFCD00210951; 4,6-O-Ethylidene-α-D-glucopyranose; 4,6-O-Ethylidene-a-D-glucose; 4,6-O-Ethylidene-α-D-glucose; (4aR,7R,8R,8aS)-2-Methylhexahydropyrano[3,2-d][1,3]dioxine-6,7,8-triol; (2R,4aR,6S,7R,8R,8aS)-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxine-6,7,8-triol; EINECS 236-496-2
- 用途
- - 生物活性
4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose) 是一种葡萄糖衍生物，是竞争性的葡萄糖转运蛋白 1 (GLUT1) 面部结合部位抑制剂，对野生型 2-脱氧-D-葡萄糖转运的 Ki 值为 12 mM。
- 靶点
GLUT1
Human Endogenous Metabolite
- 体外研究
4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose) shows poor affinity for malarial hexose transporter (PfHT1; K
i
>50 mM). 4,6-O-ethylidene-α-D-glucose inhibits wild-type transport with a K
i
of approximately 12 mM, but this is increased to greater than 120 mM in the Gln282-Leu mutant.
4,6-O-ethylidene-α-D-glucose inhibits glucose exit competitively but its penetration into human red cells is unaffected by glucose in the medium. The potentiation of the development of FDNB inhibition by sugars in the incubating medium is absent when 4,6-O-ethylidene-α-D-glucose is used and there is a slight protective action. 4,6-O-ethylidene-α-D-glucose penetrates human red cells by simple diffusion supported by its penetration of guinea-pig red cells at similar rates, by the occurrence of osmotic haemolysis in isosmotic solutions which is unaffected by copper ions and by the relatively high ether/water partition of the compound.
