- 英文名称
- (1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
- 分子式
- C25H38O5
- 分子量
- 418.57
- 中文别名
- 辛伐他汀; (1s-(1-alpha,3-dro-4-hydroxy-6-oxo-2h-pyran-2-yl)ethyl)-1-naphthalenyleste; 7-beta,8-beta(2s*,4s*),8a-beta))-alph; 2,2-Dimethylbutanoic acid 1,2,3,7,8,8α-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthyl ester; Lodaiès; [(1S,3R,7R,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-oxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoat; Butanoic acid, 2,2-dimethyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro- 4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1-alpha,3-alpha,7- beta,8-beta(2S*,4S*),8a-beta)); [8-[2-(4-Hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl]2,2-dimethylbutanoate; 2,2-Dimethylbutanoic acid (1S)-1,2,3,7,8,8aα-hexahydro-3β,7α-dimethyl-8α-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]naphthalen-1β-yl ester
- 用途
- 是具有口服活性的HMG-CoA还原酶竞争性抑制剂，可减少胆固醇的合成，降低血液中的胆固醇水平；降血脂类药物，具有降低胆固醇、低密度脂蛋白胆固醇和极低密度脂蛋白胆固醇的作用；可提高高密度脂蛋白胆固醇和降低甘油三酯；适用于原发性高胆固醇血症、杂合子家族性和非家族性高胆固醇血症或混合型高脂血症等；临床用于饮食疗法效果不佳的相关高脂血症，对无并发症且控制良好的糖尿病高胆固醇血症也有效。
