- 英文名称
- (D-Ala7)-Angiotensin I/II (1-7)
- 分子式
- C39H60N12O11
- 分子量
- 872.97
- 中文别名
- A 779; 化合物A 779; 5-L-异亮氨酸-7-D-丙氨酸-1-7-血管紧张素 II; 5-L-异亮氨酸-7-D-丙氨酸-1-7-血管紧缩素 II; 拮抗剂多肽A-779; (2R,5S,8S,11S,14S,17S,20S)-5-((1H-咪唑-4-基)甲基)-20-氨基-8-((S)-仲丁基)-17-(3-胍基丙基)-11-(4-羟基苄基)-14-异丙基-2-甲基-4,7,10,13,16,19-六氧代-3,6,9,12,15,18-六氮杂二十二烷二酸; A 779; A-779; A779; DRVYIHA; ASP-ARG-VAL-TYR-ILE-HIS-D-ALA; H-ASP-ARG-VAL-TYR-ILE-HIS-D-ALA-OH; L-α-Aspartyl-N-(diaminomethylene)-L-ornithyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-D-alanine; L-alpha-Aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-D-alanine; Ang(1-7) D-Ala7; (3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(1R)-1-carboxyethyl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid; (2R,5S,8S,11S,14S,17S,20S)-5-((1H-Imidazol-4-yl)methyl)-20-amino-8-((S)-sec-butyl)-17-(3-guanidinopropyl)-11-(4-hydroxybenzyl)-14-isopropyl-2-methyl-4,7,10,13,16,19-hexaoxo-3,6,9,12,15,18-hexaazadocosanedioic acid
- 用途
- A 779 is a G protein-coupled receptor Mas antagonist (Ang1-7 receptor). In vitro: inhibits Ang-(1-7) effects on PCNA, VSMC proliferation/migration, and inflammatory responses (MCP-1, VCAM-1, IL-1β). In vivo: elevates bone markers (BALP, CTX, TRAcP 5b, OC, DPD) in OVX rats; blocks captopril's bone protective effects and Ang1-7/Mas pathway downregulation.
