- 英文名称
- (1S,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (S)-2-methylbutanoate
- 分子式
- C23H34O5
- 分子量
- 390.51
- 中文别名
- 美伐他汀; ML 236B; Mevastatinum [INN-Latin]; mevastatin; Compactin (penicillium); Antibiotic ML 236B; L66 AU IUTJ EOVY2&1 H1 G2- FT6OVTJ DQ &&stereoisomer; Mevastatin (Compactin); MFCD05662341; Statin I; [(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate; (+)-Compactin; ML 236 B; (1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydro-1-naphthalenyl (2S)-2-methylbutanoate; 2b-Methyl-8a-(2-methyl-1-oxobutoxy)mevinic acid lactone; ML-236B; (1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate; 7-[1,2,6,7,8,8a-Hexahydro-2-methyl-8-(methylbutyryloxy)naphthyl]-3-hydroxyheptan-5-olide; [1S-[1a(R*),7b,8b(2S*,4S*),8ab]]-2-Methylbutanoic acid 1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester; Compactin; Lovastatin Impurity 1
- 用途
- 化学合成；生命科学。作为竞争性HMG-CoA还原酶抑制剂，用于降胆固醇，增加eNOS mRNA和蛋白质水平，减少梗死面积，提高神经功能缺陷，通过竞争性抑制肝胆固醇产生降低血清胆固醇水平。
