- 英文名称
- Sodium (8R,9S,13S,14S,17S)-3-((bis(2-chloroethyl)carbamoyl)oxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl phosphate
- 分子式
- C23H30Cl2NNa2O6P
- 分子量
- 564.34
- 中文别名
- Estramustine phosphate sodium; EINECS 257-735-7; Estramustine phosphate disodium; Ro 21-8837/001; Estramustine sodium phosphate; iumphosphate; estracytsodium; Estracyt; carbamic acid, bis(2-chloroethyl)-, (17β)-17-(phosphonooxy)estra-1,3,5(10)-trien-3-yl ester, disodium salt; disodium (8R,9S,13S,14S,17S)-3-{[bis(2-chloroethyl)carbamoyl]oxy}-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl phosphate; Disodium (17β)-3-{[bis(2-chloroethyl)carbamoyl]oxy}estra-1(10),2,4-trien-17-yl phosphate; Carbamic acid, N,N-bis(2-chloroethyl)-, (17β)-17-(phosphonooxy)estra-1(10),2,4-trien-3-yl ester, sodium salt (1:2); MFCD00866320; estramustinephosphatedisodium; estramustine phosphate; emcyt; Dinatrium-(8R,9S,13S,14S,17S)-3-{[bis(2-chlorethyl)carbamoyl]oxy}-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ylphosphat; Estramustine phosphate sodium; phosphate de (8R,9S,13S,14S,17S)-3-{[bis(2-chloroéthyl)carbamoyl]oxy}-13-méthyl-7,8,9,11,12,13,14,15,16,17-décahydro-6H-cyclopenta[a]phénanthrén-17-yle de disodium; Estramustine (phosphate sodium)
- 用途
- 作为抗肿瘤药，具有独特双重作用模式；代谢产物estrone和estradiol有抗促性腺激素活性，可降低睾丸激素水平；细胞毒性代谢产物estramustine能抗微管，诱导前列腺癌细胞凋亡；可通过降低miR-31诱导PC3细胞凋亡；体内能抑制肿瘤生长；选择性被前列腺细胞摄取，通过干扰微管动力学和降低睾酮水平发挥抗肿瘤作用。
