综合文献
C H Activation: A Complementary Tool in theTotal Synthesisof ComplexNatural Products
- 发布日期
- 作者
- David Y.-K. Chen; So Won Youn; Prof. Dr. David Y.-K. Chen; Prof. Dr. So Won Youn
摘要
The recent advent of transition-metal mediated C H activation is revolutionizing the synthetic field and gradually infusing a “C H activation mind-set” in both students and practitioners of organic synthesis. As a powerful testament of this emerging synthetic tool, applications of C H activation in the context of total synthesis of complex natural products are beginning to blossom. Herein, recently completed total syntheses showcasing creative and ingenious incorporation of C H activation as a strategic manoeuver are compared with their “non-C H activation” counterparts, illuminating a new paradigm in strategic synthetic design.