Near-infraredfluorescent probesfor the detection of cancer-associated proteases

Abstract Click to copy section link Section link copied! High Resolution Image Download MS PowerPoint Slide Proteases are enzymes capable of catalyzing protein breakdown, which is critical across many biological processes. There are several families of proteases, each of which perform key functions through the degradation of specific proteins. As our understanding of cancer improves, it has been demonstrated that several proteases can be overactivated during the progression of cancer and contribute to malignancy. Optical imaging systems that employ near-infrared (NIR) fluorescent probes to detect protease activity offer clinical promise, both for early detection of cancer as well as for the assessment of personalized therapy. In this Review, we review the design of NIR probes and their successful application for the detection of different cancer-associated proteases. This publication is licensed under CC-BY 4.0 . License Summary* You are free to share (copy and redistribute) this

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review the actual license before using these materials. License Summary* You are free to share (copy and redistribute)

this article in any medium or format and to adapt (remix, transform, and build upon) the material for any

purpose, even commercially within the parameters below: Creative Commons (CC): This is a Creative Commons

license. Attribution (BY): Credit must be given to the creator. View

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actual license. It is not a license and has no legal value.

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review the actual license before using these materials. ACS Publications Copyright © 2021 The Authors. Published by American Chemical Society Subjects what are subjects Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. Cancer Fluorescence Peptides and proteins Probes Rodent models