活性蓝4; 活性蓝 4-琼脂糖; 普施安蓝 MX-R; 1-氨基-4-[3-(4,6-二氯三唑-2-基氨基)-4-磺酰苯氨基]蒽醌二磺酸; C.I.活性蓝4; 活性艳蓝X-BR; 1-Amino-4-[[3-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-4-sulfophenyl]amino]-9,10-dihydro-9,10-dioxo-2-anthracenesulfonic acid; Mikacion Brilliant Blue S-R; Procion Blue MX-R; Active Brilliant Sky Blue KKH; Ambifix Blue CR
活性蓝 M-GR; 活性深蓝 F-4G; 活性深蓝 KM-GR; Drimarene Blue R-GL; Drimarene Navy R-GL; Levafix Blue P-RA; Blue R-GL CDG; Blue KM-GR; C.I.Reactive Blue 104; Drimarene Blue R-GL CDG
活性蓝 K-GL; 活性翠蓝K-GL; C.I.活性蓝14; Cibacron Brilliant Blue FC-4GP; Turqoise Blue K-GR; Reactive Blue Green K-GL; Reactive Brilliant Blue K-GL; Reactive Emerald Blue K-GL; Reactive Green Blue K-GL; C.I.Reactive Blue 14
兰色染料; 蓝色染料; 汽巴蓝F3GA; 汽巴蓝3GA琼脂糖; 汽巴蓝/兰色染料; C.I.活性蓝2; 化合物T19049; Procion Blue HB; CIBRACONBLUEF3GA; Kayacion Blue A-B; C.I.REACTIVEBLUE2; Reactive blue 2 (C.I. 61211); 1-Amino-4-[[4-[[4-chloro-6-[[4-(sodiooxysulfonyl)phenyl]amino]-1,3,5-triazin-2-yl]amino]-3-(sodiooxysulfonyl)phenyl]amino]-9,10-dihydro-9,10-dioxo-2-anthracenesulfonic acid sodium salt
用途
- 生物活性
Procion Blue HB (Reactive Blue 2)是嘌呤能拮抗剂。
- 体外研究
Reactive Blue 2 is used as an ATP receptor antagonist and induces Ca
2+
oscillations in HeLa cells. Reactive Blue 2 enhances a Ca
2+
response to histamine that is linked to the PLC cascade. Reactive Blue 2 may activate the PLC cascade in an extracellular Ca
2+
-dependent manner and induce Ca
2+
oscillations. The application of Reactive Blue 2 increases K
+
secretion in a dose-dependent manner, and this increase is characterized as a peak followed by a partial relaxation to a steady-state. Reactive Blue 2 has antagonistic activities at P2Y4, and the antagonist potency at P2Y4 paralleled the potency of K+ secretion.The anthraquinone dye reactive blue 2 is found to be a potent inhibitor of a protein kinase isolated and purified from thylakoids. The mode of inhibition is noncompetitive, with a K
i
of 8 μM for the membrane-bound kinase, and 6 microM for the purified kinase. The inhibitor does not modify the substrate preference of the endogenous kinase and could be removed from the membrane by washing. Reactive blue 2 selectively inhibits responses mediated via the P2ypurinoceptor, at least within a limited concentration range. In preparations where the tone has been raised with noradrenaline, ATP and 2-methylthio ATP, but not α,β-methylene ATP, produce relaxations of the vessel. These relaxations are inhibited in the presence of reactive blue 2. Reactive blue 2, at concentrations of 0.3-10 μM blocks the ATP-induced oscillation in a concentration-dependent manner.
C.I.活性蓝222; 活性深蓝 KN-FBN; 活性深蓝 M-BE; 活性兰222; Reactive Brilliant Blue ME-B; Reactive Blue BF; C.I. Reactive blue 222; Navy BF; Cosmoactive Blue BF; Everzol Supra Navy Blue FBN; Itofix Navy Blue VM3GF
