908245-03-4 6-甲基-3-哌啶甲酸甲酯

名称和标识

中文名: 6-甲基-3-哌啶甲酸甲酯
英文名: Methyl 6-methylpiperidine-3-carboxylate
CAS号: 908245-03-4
分子式: C8H15NO2
分子量: 157.21
中文别名: 甲基6-甲基哌啶-3-羧酸酯; 6-甲基哌啶-3-羧酸甲酯; 6-甲基哌啶-3-甲酸甲酯; 甲基 6-甲基哌啶-3-甲酸基酯
英文别名: 3-Piperidinecarboxylic acid, 6-methyl-, methyl ester; Methyl 6-methyl-3-piperidinecarboxylate; 6-Methyl-3piperidinecarboxylic acid Methyl ester; 6-Methyl-piperidinecarboxylic acid Methyl ester

安全说明

运输信息：冰袋运输。危险描述：危险性质：否。海关编码：2933399990

用途与制备

化学合成

路线1：以6-甲基烟酸甲酯为原料

步骤：在400 mL Fisher-Porter反应器中加入甲醇（300 mL）、浓盐酸（13.0 g）、10% Pd/C催化剂（4.0 g）和6-甲基烟酸甲酯（20.0 g，132 mmol）；加热至80℃并在60 psi氢气压力下搅拌21小时；冷却后过滤去除催化剂，滤液减压蒸发得到产物。
收率：100%（定量）
产物确认：1H NMR谱与指定结构一致
参考文献： [1] Patent: US2010/93706, 2010, A1. Location in patent: Page/Page column 34 [2] Patent: EP3248980, 2017, A1. Location in patent: Paragraph 0163; 0164; 0165 [3] Patent: WO2010/124055, 2010, A1. Location in patent: Page/Page column 39-40 [4] Patent: WO2011/26917, 2011, A1. Location in patent: Page/Page column 93 [5] Patent: WO2011/26904, 2011, A1. Location in patent: Page/Page column 93 [6] Patent: WO2011/85406, 2011, A1. Location in patent: Page/Page column 132 [7] Patent: WO2012/33956, 2012, A1. Location in patent: Page/Page column 154-155 [8] Patent: WO2012/101063, 2012, A1. Location in patent: Page/Page column 167 [9] Patent: WO2012/101064, 2012, A1. Location in patent: Page/Page column 210 [10] Patent: US2016/221948, 2016, A1. Location in patent: Paragraph 0431-0433

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