80650-46-0 2-氯-N-吡啶-4-基乙酰胺

海关编码:2933399990

路线1：以4-氨基吡啶和氯乙酰氯为原料合成

• 原料：4-氨基吡啶（20mmol）、氯乙酰氯（24mmol）、三乙胺（30mmol）、乙腈（25mL）
• 条件：室温（20℃）下反应8小时
• 后处理：按照旁路操作方法II进行处理
• 收率：64.3%
• 参考文献： [1] Patent: CN105418506, 2016, A. Location in patent: Paragraph 0164 [2] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 7, p. 2514 - 2527 [3] Patent: WO2018/132372, 2018, A1. Location in patent: Paragraph 00761 [4] Tetrahedron Letters, 2005, vol. 46, # 21, p. 3761 - 3766 [5] Tetrahedron Letters, 2006, vol. 47, # 35, p. 6321 - 6324 [6] Dalton Transactions, 2015, vol. 44, # 40, p. 17800 - 17809 [7] New Journal of Chemistry, 2016, vol. 40, # 5, p. 4606 - 4616 [8] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 17, p. 4377 - 4381 [9] Patent: US2011/172237, 2011, A1. Location in patent: Page/Page column 23 [10] Angewandte Chemie - International Edition, 2017, vol. 56, # 12, p. 3309 - 3313 [11] Angew. Chem., 2017, vol. 129, # 12, p. 3357 - 3361 [12] Patent: WO2009/138707, 2009, A1. Location in patent: Page/Page column 62-63