4465-44-5 (S)-3-羟基-2-(三苯基甲基氨基)丙酸甲酯

运输方式为冰袋运输。危险性质：非危险化学品。WGK Germany:3，海关编码:29225090，存储类别:11 - 可燃固体。

化学合成

化学合成

路线1

• 步骤：将三乙胺（Et3N，13.4 mL，96.78 mmol）的二氯甲烷（CH2Cl2，40 mL）溶液缓慢滴加至含有L-丝氨酸甲酯盐酸盐（5.0 g，32.26 mmol）和三苯基氯甲烷（Ph3CCl，13.5 g，48.39 mmol）的二氯甲烷（CH2Cl2，129 mL）溶液中，反应在氮气（N2）保护下于0℃进行；随后升温至室温搅拌过夜；反应完成后，用饱和碳酸氢钠（NaHCO3）溶液淬灭反应，水相用二氯甲烷（CH2Cl2）萃取；合并有机相，用盐水洗涤，无水硫酸钠干燥，减压浓缩；粗产物通过硅胶柱色谱法纯化，得到无色固体产物。
• 条件：三乙胺作碱，二氯甲烷作溶剂，反应温度0 - 20℃，氮气保护。
• 收率：98%（11.41克）。
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