1450655-76-1 1-(1-(1-(乙基磺酰基)哌啶-4-基)乙基)-N-((4-甲氧基-6-甲基-2-氧代-1,2-二氢吡啶-3-基)甲基)-2-甲基-1H-吲哚-3-甲酰胺

中文名称: 1-(1-(1-(乙基磺酰基)哌啶-4-基)乙基)-N-((4-甲氧基-6-甲基-2-氧代-1,2-二氢吡啶-3-基)甲基)-2-甲基-1H-吲哚-3-甲酰胺
英文名称: 1-(1-(1-(ethylsulfonyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1H-indole-3-carboxamide
CAS号
分子式: C₂₇H₃₆N₄O₅S
分子量: 528.66
更新日期: 2026-06-23

名称和标识

中文名: 1-(1-(1-(乙基磺酰基)哌啶-4-基)乙基)-N-((4-甲氧基-6-甲基-2-氧代-1,2-二氢吡啶-3-基)甲基)-2-甲基-1H-吲哚-3-甲酰胺
英文名: 1-(1-(1-(ethylsulfonyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1H-indole-3-carboxamide
CAS号: 1450655-76-1
分子式: C27H36N4O5S
分子量: 528.66
中文别名: CPI-169; EZH2抑制剂CPI-169; CPI-169消旋体
英文别名: CPI-169; CPI-169 racemate; CPI169; CPI 169; 1-{(1R)-1-[1-(Ethylsulfonyl)-4-piperidinyl]ethyl}-N-[(4-methoxy-6-methyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-2-methyl-1H-indole-3-carboxamide; (R)-1-(1-(1-(ethylsulfonyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1H-indole-3-carboxamide; 1-[1-(1-ethylsulfonylpiperidin-4-yl)ethyl]-N-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methylindole-3-carboxamide; 1-{1-[1-(ethanesulfonyl)piperidin-4-yl]ethyl}-N-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2-methyl-1H-indole-3-carboxamide; 1-[(1R)-1-[1-(ethanesulfonyl)piperidin-4-yl]ethyl]-N-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2-methyl-1H-indole-3-carboxamide; 1-[1-(1-ethylsulfonyl-4-piperidinyl)ethyl]-N-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-3-indolecarboxamide; 1-[1-(1-ethylsulfonyl-4-piperidyl)ethyl]-N-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-indole-3-carboxamide; N-[(1,2-Dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-1-[1-[1-(ethylsulfonyl)-4-piperidinyl]ethyl]-2-methyl-1H-indole-3-carboxamide

物化属性

LogP: 2.67
PSA: 121.88 Å²
XLogP3-AA: 2.8
储存条件: -20℃
分子量: 528.7 g/mol
外观: 粉末或固体
密度: 1.3±0.1 g/cm³
折射率: 1.631
溶解度: DMSO中≥26.45 mg/mL；不溶于水；温和加热和超声波下，乙醇中≥2.18 mg/mL
精确质量: 528.24064144
酸度系数(pKa): 11.01±0.10 (Predicted)

生产及用途

用途与制备

CPI-169是有效的选择性EZH2抑制剂，对EZH2 WT、EZH2 Y641N和EZH1的IC50分别为0.24 nM、0.51 nM和6.1 nM；在KARPAS-422细胞中呈剂量依赖性抑制细胞活性，与ABT-199联合有协同抗增殖作用，对16个NHL细胞系（共25个）GI50<5 μM；体内给药200 mg/kg皮下注射可抑制H3K27me3水平，使淋巴肿瘤退化且无体重影响或明显副作用。

医药

词条详情加载中…

1450655-76-1 1-(1-(1-(乙基磺酰基)哌啶-4-基)乙基)-N-((4-甲氧基-6-甲基-2-氧代-1,2-二氢吡啶-3-基)甲基)-2-甲基-1H-吲哚-3-甲酰胺

中文名称

1-(1-(1-(乙基磺酰基)哌啶-4-基)乙基)-N-((4-甲氧基-6-甲基-2-氧代-1,2-二氢吡啶-3-基)甲基)-2-甲基-1H-吲哚-3-甲酰胺

英文名称

1-(1-(1-(ethylsulfonyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1H-indole-3-carboxamide

CAS号

分子式

C₂₇H₃₆N₄O₅S

分子量

528.66

更新日期

2026-06-23