1425381-60-7 古沙替尼

名称和标识

中文名: 古沙替尼
英文名: Gusacitinib
CAS号: 1425381-60-7
分子式: C24H28N8O2
分子量: 460.53
中文别名: 2-(1-(4-((4-(4-羟基哌啶-1-基)苯基)氨基)-5-氧代-5,6-二氢嘧啶并[4,5-d]哒嗪-2-基)哌啶-4-基)乙腈; ASN-002; 1-[5,6-二氢-4-[[4-(4-羟基-1-哌啶基)苯基]氨基]-5-氧代嘧啶并[4,5-D]哒嗪-2-基]-4-哌啶乙腈
英文别名: ASN-002; ASN002; 2-(1-(4-((4-(4-Hydroxypiperidin-1-yl)phenyl)amino)-5-oxo-5,6-dihydropyrimido[4,5-d]pyridazin-2-yl)piperidin-4-yl)acetonitrile; 1-(4-(4-(4-Hydroxy-piperidin-1-yl)-phenylamino)-5-oxo-5,6-dihydro-pyrimido(4,5-D)pyridazin-2-yl)-piperidin-4-YL-acetonitrile; 4-Piperidineacetonitrile, 1-(5,6-dihydro-4-((4-(4-hydroxy-1-piperidinyl)phenyl)amino)-5-oxopyrimido(4,5-d)pyridazin-2-yl)-; gusacitinibum; 2-(1-(4-((4-(4-hydroxypiperidin-1-yl)phenyl)amino)-5-oxo-5H,6H-pyrimido(4,5-d)pyridazin-2-yl)piperidin-4-yl)acetonitrile; 2-[1-(4-{[4-(4-hydroxypiperidin-1-yl)phenyl]amino}-5-oxo-5H,6H-pyrimido[4,5-d]pyridazin-2-yl)piperidin-4-yl]acetonitrile; 2-[1-[4-[4-(4-hydroxypiperidin-1-yl)anilino]-5-oxo-6H-pyrimido[4,5-d]pyridazin-2-yl]piperidin-4-yl]acetonitrile; 1-[5,6-Dihydro-4-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5-oxopyrimido[4,5-d]pyridazin-2-yl]-4-piperidineacetonitrile

安全说明

运输方式：冰袋运输。危险描述：吞咽有害（H302）；对水生生物有长期毒性（H410）。防护措施：P264、P270、P273、P301+P317、P330、P391、P501。危险类别：急性毒性4级；水生环境慢性1级。

用途与制备

生命科学领域，作为 SYK 激酶和 JAK 激酶的双抑制剂，用于特应性皮炎、慢性手部湿疹及癌症（如基底细胞癌）的研究，能快速显著抑制特应性皮炎发病机制相关关键炎症通路。

医药

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