141636-65-9 GR 94800

名称和标识

中文名: GR 94800
英文名: GR 94800
CAS号: 141636-65-9
分子式: C49H61N9O8
分子量: 904.06
中文别名: BZ-ALA-ALA-D-TRP-PHE-D-PRO-PRO-NLE-NH2; 化合物 T22811; 拮抗剂多肽GR 94800; 化合物 GR 94800; 七肽Bz-AA-DTrp-F-DPro-P-Nle-NH2; (2S)-1-((2R)-1-((3S,6S,12S)-9-((1H-吲哚-3-基)甲基)-12-苄基-3,6-二甲基-1,4,7,10-四氧代-1-苯基-2,5,8,11-四氮杂十三烷-13-OYL)吡咯烷-2-羰基)-N-((S)-1-氨基-1-氧代己-2-基)吡咯烷-2-甲酰胺
英文别名: GR-94800; GR94800; (2S)-N-[(2S)-1-amino-1-oxohexan-2-yl]-1-[(2R)-1-[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-benzamidopropanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxamide; N-alpha-Benzoylalanyl-alanyl-tryptophyl-phenylalanyl-prolyl-prolyl-norleucinamide; Nalpha-Benzoyl-ala-ala-D-trp-phe-D-pro-pro-nle-NH2; L-Norleucinamide, N-benzoyl-L-alanyl-L-alanyl-D-tryptophyl-L-phenylalanyl-D-prolyl-L-prolyl-; N-alpha-benzoyl-Ala-Ala-D-Trp-Phe-D-Pro-Pro-Nle-NH2; PhCO-Ala-Ala-D-Trp-Phe-D-Pro-Pro-Nle-NH2; N-Benzoyl-L-alanyl-L-alanyl-D-tryptophyl-L-phenylalanyl-D-prolyl-L-prolyl-L-norleucinamide; Bz-Ala-Ala-D-Trp-Phe-D-Pro-Pro-Nle-NH2; (2S)-1-((2R)-1-((3S,6S,12S)-9-((1H-indol-3-yl)methyl)-12-benzyl-3,6-dimethyl-1,4,7,10-tetraoxo-1-phenyl-2,5,8,11-tetraazatridecan-13-oyl)pyrrolidine-2-carbonyl)-N-((S)-1-amino-1-oxohexan-2-yl)pyrrolidine-2-carboxamide

安全说明

运输方式为冰袋运输。危险性质：非危险化学品。WGK Germany:3

用途与制备

生物活性：GR 94800是有效的、选择性的神经激肽2 (NK2)受体的肽类拮抗剂，其对NK2、NK1和NK3受体的pKB值分别为9.6、6.4和6.0；- 体外研究：Responses to EFS (15 Hz) were significantly reduced by the NK2 receptor antagonist GR 94800 (1 μM) either alone or in combination with the NK1 antagonist (1 μM)。

医药

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